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23S rRNA (adenine1618-N6)-methyltransferase

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23S rRNA (adenine1618-N6)-methyltransferase
Identifiers
EC no.2.1.1.181
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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NCBIproteins

23S rRNA (adenine1618-N6)-methyltransferase (EC 2.1.1.181, rRNA large subunit methyltransferase F, YbiN protein, rlmF (gene), m6A1618 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine1618-N6)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine1618 in 23S rRNA S-adenosyl-L-homocysteine + N6-methyladenine1618 in 23S rRNA

The recombinant YbiN protein is able to methylate partially deproteinized 50 S ribosomal subunit.

References

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  1. ^ Sergiev PV, Serebryakova MV, Bogdanov AA, Dontsova OA (January 2008). "The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel". Journal of Molecular Biology. 375 (1): 291–300. doi:10.1016/j.jmb.2007.10.051. PMID 18021804.
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