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23S rRNA (guanosine2251-2'-O)-methyltransferase

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23S rRNA (guanosine2251-2'-O)-methyltransferase
Identifiers
EC no.2.1.1.185
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

23S rRNA (guanosine2251-2'-O)-methyltransferase (EC 2.1.1.185, rlmB (gene), yifH (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O-)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanosine2251 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA

The enzyme catalyses the methylation of guanosine2251.

References

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  1. ^ Lövgren JM, Wikström PM (December 2001). "The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli". Journal of Bacteriology. 183 (23): 6957–60. doi:10.1128/jb.183.23.6957-6960.2001. PMC 95539. PMID 11698387.
  2. ^ Michel G, Sauvé V, Larocque R, Li Y, Matte A, Cygler M (October 2002). "The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot". Structure. 10 (10): 1303–15. doi:10.1016/s0969-2126(02)00852-3. PMID 12377117.
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