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5-phosphonooxy-L-lysine phospho-lyase

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5-phosphonooxy-L-lysine phospho-lyase
Identifiers
EC no.4.2.3.134
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5-Phosphonooxy-L-lysine phospho-lyase (EC 4.2.3.134, 5-phosphohydroxy-L-lysine ammoniophospholyase, AGXT2L2 (gene)) is an enzyme with systematic name (5R)-5-phosphonooxy-L-lysine phosphate-lyase (deaminating; (S)-2-amino-6-oxohexanoate-forming).[1][2] This enzyme catalyses the following chemical reaction

(5R)-5-phosphonooxy-L-lysine + H2O (S)-2-amino-6-oxohexanoate + NH3 + phosphate

This enzyme is a pyridoxal-phosphate protein.

References

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  1. ^ Tsai CH, Henderson LM (September 1974). "Degradation of O-phosphohydroxylysine by rat liver. Purification of the phospho-lyase". The Journal of Biological Chemistry. 249 (18): 5784–9. doi:10.1016/S0021-9258(20)79885-6. PMID 4412716.
  2. ^ Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E (March 2012). "Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine". The Journal of Biological Chemistry. 287 (10): 7246–55. doi:10.1074/jbc.m111.323485. PMC 3293546. PMID 22241472.
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