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AADAC

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AADAC
Identifiers
AliasesAADAC, CES5A1, DAC, arylacetamide deacetylase
External IDsOMIM: 600338; MGI: 1915008; HomoloGene: 37436; GeneCards: AADAC; OMA:AADAC - orthologs
EC number3.1.1.3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001086

NM_023383

RefSeq (protein)

NP_001077

NP_075872

Location (UCSC)Chr 3: 151.81 – 151.83 MbChr 3: 59.93 – 59.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arylacetamide deacetylase is an enzyme that in humans is encoded by the AADAC gene.[5][6]

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114771Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027761Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Probst MR, Beer M, Beer D, Jeno P, Meyer UA, Gasser R (Sep 1994). "Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase". J Biol Chem. 269 (34): 21650–6. doi:10.1016/S0021-9258(17)31855-0. PMID 8063807.
  6. ^ a b "Entrez Gene: AADAC arylacetamide deacetylase (esterase)".

Further reading

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