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ACSS3

From Wikipedia, the free encyclopedia
ACSS3
Identifiers
AliasesACSS3, acyl-CoA synthetase short-chain family member 3, acyl-CoA synthetase short chain family member 3
External IDsOMIM: 614356; MGI: 2685720; HomoloGene: 11587; GeneCards: ACSS3; OMA:ACSS3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024560
NM_001330242
NM_001330243

NM_001142804
NM_198636

RefSeq (protein)

NP_001317171
NP_001317172
NP_078836

NP_001136276
NP_941038

Location (UCSC)Chr 12: 80.94 – 81.26 MbChr 10: 106.77 – 106.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acyl-CoA synthetase short-chain family member 3 is a protein that in humans is encoded by the ACSS3 gene.[5]

Function

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ACSS3 is part of a family known as Acyl-coenzyme A synthetases (ACSs), which catalyze the initial reaction in fatty acid metabolism. This reaction activates fatty acids via thioesterification to CoA, thereby allowing their participation in both anabolic and catabolic pathways. The existence of many ACSs suggests that each plays a unique role, directing the acyl-CoA product to a specific metabolic fate. Knowing the full complement of ACS genes in the human genome will facilitate future studies to characterize their specific biological functions.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111058Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035948Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Acyl-CoA synthetase short-chain family member 3".
  6. ^ Watkins PA, Maiguel D, Jia Z, Pevsner J (Dec 2007). "Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome". Journal of Lipid Research. 48 (12): 2736–50. doi:10.1194/jlr.M700378-JLR200. PMID 17762044.

Further reading

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