Jump to content

ADCK5

From Wikipedia, the free encyclopedia
ADCK5
Identifiers
AliasesADCK5, aarF domain containing kinase 5
External IDsMGI: 2679274; HomoloGene: 34378; GeneCards: ADCK5; OMA:ADCK5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_174922

NM_172960

RefSeq (protein)

NP_777582

NP_766548

Location (UCSC)Chr 8: 144.37 – 144.39 MbChr 15: 76.46 – 76.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ADCK5 (aarF domain containing kinase 5) is an enzyme that in humans is encoded by the ADCK5 gene. It is situated on chromosome 8 at the q24.3 location.

Function

[edit]

ADCK5 is predicted to possess protein serine/threonine kinase activity and to be an integral component of the membrane.[5]

Genomic context

[edit]

The ADCK5 gene is located on chromosome 8q24.3. The genomic sequence spans 20,154 base pairs from 144,373,088 to 144,393,242 on the GRCh38.p14 primary assembly. It consists of 19 exons.[5]

Expression

[edit]

ADCK5 is ubiquitously expressed across various human tissues, with notable expression in the duodenum and small intestine, among others.[5]

Clinical significance

[edit]

Research indicates that ADCK5 may have therapeutic implications in lung cancer.[6]

References

[edit]
  1. ^ a b c ENSG00000285451 GRCh38: Ensembl release 89: ENSG00000173137, ENSG00000285451Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022550Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "ADCK5 aarF domain containing kinase 5 [Homo sapiens (Human)] - Gene - NCBI".
  6. ^ Qiu, M; Li, G; Wang, P; Li, X; Lai, F; Luo, R; Liu, B; Lin, J (1 July 2020). "aarF domain containing kinase 5 gene promotes invasion and migration of lung cancer cells through ADCK5-SOX9-PTTG1 pathway". Experimental Cell Research. 392 (1): 112002. doi:10.1016/j.yexcr.2020.112002. PMID 32277958.