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AKAP7

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AKAP7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAKAP7, AKAP15, AKAP18, A-kinase anchoring protein 7
External IDsOMIM: 604693; MGI: 1859150; HomoloGene: 49463; GeneCards: AKAP7; OMA:AKAP7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018747
NM_001347460
NM_001379238
NM_001379239
NM_001379240

RefSeq (protein)

NP_004833
NP_057461
NP_619539
NP_001363499
NP_057461.2

Location (UCSC)Chr 6: 131.14 – 131.28 MbChr 10: 25.04 – 25.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

A-kinase anchor protein 7 isoform gamma is an enzyme that in humans is encoded by the AKAP7 gene.[5][6]

Function

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This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118507Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039166Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, Marrion NV, Scott JD (Apr 1998). "A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events". The EMBO Journal. 17 (8): 2261–2272. doi:10.1093/emboj/17.8.2261. PMC 1170570. PMID 9545239.
  6. ^ a b "Entrez Gene: AKAP7 A kinase (PRKA) anchor protein 7".
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Further reading

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