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ANAPC5

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ANAPC5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC5, APC5, anaphase promoting complex subunit 5
External IDsOMIM: 606948; MGI: 1929722; HomoloGene: 41118; GeneCards: ANAPC5; OMA:ANAPC5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001137559
NM_016237
NM_001330489

RefSeq (protein)

NP_001131031
NP_001317418
NP_057321

Location (UCSC)Chr 12: 121.31 – 121.4 MbChr 5: 122.93 – 122.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.[5][6]

The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM][6]

Interactions

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ANAPC5 has been shown to interact with ANAPC1,[7][8] ANAPC4,[7] CDC27[7][9][10] and PABPC1.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089053Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029472Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
  6. ^ a b "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".
  7. ^ a b c Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. S2CID 5942532.
  8. ^ Sumara I, Vorlaufer E, Gieffers C, Peters B H, Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.
  9. ^ a b Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753. PMID 15082755.
  10. ^ Gmachl M, Gieffers C, Podtelejnikov A V, Mann M, Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056.
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Further reading

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