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ANAPC7

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ANAPC7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC7, APC7, anaphase promoting complex subunit 7, FERBON
External IDsOMIM: 606949; MGI: 1929711; HomoloGene: 10512; GeneCards: ANAPC7; OMA:ANAPC7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019805

RefSeq (protein)

NP_001131136
NP_057322
NP_057322.2

NP_062779

Location (UCSC)Chr 12: 110.37 – 110.4 MbChr 5: 122.56 – 122.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[5] Multiple transcript variants encoding different isoforms have been found for this gene.

Function

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This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[5]

Interactions

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ANAPC7 has been shown to interact with ANAPC1,[6][7] ANAPC4,[6] CDC27[6][8] and CDC20.[6][9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196510Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029466Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7".
  6. ^ a b c d Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  7. ^ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  8. ^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  9. ^ Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.
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Further reading

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