Jump to content

ARHGAP9

From Wikipedia, the free encyclopedia
ARHGAP9
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesARHGAP9, 10C, RGL1, Rho GTPase activating protein 9
External IDsOMIM: 610576; MGI: 2143764; HomoloGene: 13041; GeneCards: ARHGAP9; OMA:ARHGAP9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001285785
NM_146011
NM_001359656
NM_001359657

RefSeq (protein)

n/a

Location (UCSC)Chr 12: 57.47 – 57.49 MbChr 10: 127.16 – 127.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene.[5][6]

Function

[edit]

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123329Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040345Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Furukawa Y, Kawasoe T, Daigo Y, Nishiwaki T, Ishiguro H, Takahashi M, Kitayama J, Nakamura Y (Jun 2001). "Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643–9. doi:10.1006/bbrc.2001.5022. PMID 11396949.
  6. ^ a b "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9".
[edit]

Further reading

[edit]