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ARHGEF4

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ARHGEF4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARHGEF4, ASEF, ASEF1, GEF4, STM6, Rho guanine nucleotide exchange factor 4, SMIM39
External IDsOMIM: 605216; MGI: 2442507; HomoloGene: 49414; GeneCards: ARHGEF4; OMA:ARHGEF4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_183019
NM_001368773

RefSeq (protein)

NP_898840
NP_001355702

Location (UCSC)Chr 2: 130.84 – 131.05 MbChr 1: 34.68 – 34.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho guanine nucleotide exchange factor 4 is a protein that in humans is encoded by the ARHGEF4 gene.[5][6]

Function

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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.[6]

Interactions

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ARHGEF4 has been shown to interact with APC.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136002Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037509Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Thiesen S, Kübart S, Ropers HH, Nothwang HG (Jul 2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem Biophys Res Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
  6. ^ a b "Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4".
  7. ^ Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, et al. (2000). "Asef, a link between the tumor suppressor APC and G-protein signaling". Science. 289 (5482): 1194–7. Bibcode:2000Sci...289.1194K. doi:10.1126/science.289.5482.1194. PMID 10947987.
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Further reading

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