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ARIH2

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ARIH2
Identifiers
AliasesARIH2, ARI2, TRIAD1, ariadne RBR E3 ubiquitin protein ligase 2
External IDsOMIM: 605615; MGI: 1344361; HomoloGene: 48424; GeneCards: ARIH2; OMA:ARIH2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006321
NM_001317333
NM_001317334

NM_011790
NM_001357283
NM_001357285
NM_001357286

RefSeq (protein)

NP_035920
NP_001344212
NP_001344214
NP_001344215

Location (UCSC)n/aChr 9: 108.48 – 108.53 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.[4][5]

Function

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ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulate the proliferation,[6] DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination,[7] ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.[8]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064145Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (July 1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Science. 8 (7): 1557–1561. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847.
  5. ^ "Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila)".
  6. ^ Wang H, Bei L, Shah CA, Huang W, Platanias LC, Eklund EA (May 2018). "The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia". Oncogene. 37 (19): 2532–2544. doi:10.1038/s41388-018-0131-5. PMC 5945580. PMID 29459712.
  7. ^ Geng S, Peng W, Wang X, Hu X, Liang H, Hou J, et al. (June 2022). "ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination". Cell Death & Disease. 13 (6): 564. doi:10.1038/s41419-022-04965-9. PMC 9218151. PMID 35732617.
  8. ^ Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, et al. (November 2017). "ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages". Journal of Immunology. 199 (10): 3614–3622. doi:10.4049/jimmunol.1700184. PMID 29021376.
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Further reading

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