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ARPC2

From Wikipedia, the free encyclopedia
ARPC2
Identifiers
AliasesARPC2, ARC34, PNAS-139, p34-Arc, PRO2446, actin related protein 2/3 complex subunit 2
External IDsOMIM: 604224; MGI: 1923959; HomoloGene: 4187; GeneCards: ARPC2; OMA:ARPC2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005731
NM_152862

NM_029711
NM_001357387

RefSeq (protein)

NP_005722
NP_690601

NP_083987
NP_001344316

Location (UCSC)Chr 2: 218.22 – 218.25 MbChr 1: 74.28 – 74.31 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-related protein 2/3 complex subunit 2 is a protein that in humans is encoded by the ARPC2 gene.[5][6][7]

Function

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This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.[7]

Interactions

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ARPC2 has been shown to interact with Cortactin.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163466Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006304Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (1997). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 ( Pt 1) (Pt 1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
  6. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (August 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J. Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  7. ^ a b "Entrez Gene: ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa".
  8. ^ Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT (October 2000). "Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex". J. Cell Biol. 151 (1): 29–40. doi:10.1083/jcb.151.1.29. PMC 2189811. PMID 11018051.
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Further reading

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