Acrodynia
| Acrodynia | |
|---|---|
| Other names | Bilderbeck's, Selter's, Swift's and Swift-Feer disease. |
| Specialty | Emergency medicine  |
Acrodynia is a medical condition which occurs due to mercury poisoning. The condition of pain and dusky pink discoloration in the hands and feet is due to exposure or ingesting of mercury. It was known as pink disease (due to these symptoms) before it was accepted that it was just mercury poisoning.[1] The word acrodynia is derived from the Greek: ακρος, which means end or extremity, and Greek: οδυνη, which means pain. As such, it might be (erroneously) used to indicate that a patient has pain in the hands or feet. The condition is known by various other names including hydrargyria, mercurialism, erythredema, erythredema polyneuropathy, Bilderbeck's, Selter's, Swift's and Swift-Feer disease.
Symptoms and signs
[edit]Besides peripheral neuropathy (presenting as paresthesia or itching, burning or pain) and discoloration, swelling (edema) and desquamation may occur. Since mercury blocks the degradation pathway of catecholamines, epinephrine excess causes profuse sweating (diaphora), tachycardia, salivation and elevated blood pressure. Mercury is suggested to inactivate S-adenosyl-methionine, which is necessary for catecholamine catabolism by catechol-o-methyl transferase. Affected children may show red cheeks and nose, red (erythematous) lips, loss of hair, teeth, and nails, transient rashes, hypotonia and photophobia. Other symptoms may include kidney dysfunction (e.g. Fanconi syndrome) or neuropsychiatric symptoms (emotional lability, memory impairment, insomnia).[citation needed]
Thus, the clinical presentation may resemble pheochromocytoma or Kawasaki disease.[citation needed]
There is some evidence that the same mercury poisoning may predispose to Young's syndrome (men with bronchiectasis and low sperm count).[2]
Causes
[edit]Mercury compounds like calomel were historically used for various medical purposes: as laxatives, diuretics, antiseptics or antimicrobial drugs for syphilis, typhus and yellow fever.[3] Teething powders were a widespread source of mercury poisoning until the recognition of mercury toxicity in the 1940s.[4]
However, mercury poisoning and acrodynia still exist today.[5] Modern sources of mercury intoxication include broken thermometers.[6]
Diagnosis
[edit]Removal of the inciting agent is the goal of treatment. Correcting fluid and electrolyte losses and rectifying any nutritional imbalances (vitamin-rich diets, vitamin-B complex) are of utmost importance in the treatment of the disease.[citation needed]
The chelating agent meso 2,3-dimercaptosuccinic acid has been shown to be the preferred treatment modality. It can almost completely prevent methylmercury uptake by erythrocytes and hepatocytes. In the past, dimercaprol (British antilewisite; 2,3-dimer-capto-l-propanol) and D-penicillamine were the most popular treatment modalities. Disodium edetate (Versene) was also used. Neither disodium edetate nor British antilewisite has proven reliable. British antilewisite has now been shown to increase CNS levels and exacerbate toxicity. N -acetyl-penicillamine has been successfully given to patients with mercury-induced neuropathies and chronic toxicity, although it is not approved for such uses. It has a less favorable adverse effect profile than meso 2,3-dimercaptosuccinic acid. [citation needed]
Hemodialysis with and without the addition of L-cysteine as a chelating agent has been used in some patients experiencing acute kidney injury from mercury toxicity. Peritoneal dialysis and plasma exchange also may be of benefit.[citation needed]
Tolazoline (Priscoline) has been shown to offer symptomatic relief from sympathetic overactivity. Antibiotics are necessary when massive hyperhidrosis, which may rapidly lead to miliaria rubra, is present.[citation needed] This can easily progress to bacterial secondary infection with a tendency for ulcerating pyoderma.[citation needed]
References
[edit]- ^ Horowitz Y, Greenberg D, Ling G, Lifshitz M (2002). "Acrodynia: a case report of two siblings". Arch Dis Child. 86 (6): 453. doi:10.1136/adc.86.6.453. PMC 1762992. PMID 12023189.
- ^ Hendry WF, A'Hern FPA, Cole PJ (1993). "Was Young's syndrome caused by mercury exposure in childhood?". BMJ. 307 (6919): 1579–82. doi:10.1136/bmj.307.6919.1579. PMC 1697782. PMID 8292944.
- ^ Beck C, Krafchik B, Traubici J, Jacobson S (2004). "Mercury intoxication: it still exists". Pediatr Dermatol. 21 (3): 254–9. doi:10.1111/j.0736-8046.2004.21314.x. PMID 15165207. S2CID 7970810.
- ^ Dally, Ann (1997). "The Rise and Fall of Pink Disease". Social History of Medicine. 10 (2): 291–304. doi:10.1093/shm/10.2.291. PMID 11619497.
- ^ Weinstein M, Bernstein S (2003). "Pink ladies: mercury poisoning in twin girls". CMAJ. 168 (2): 201. PMC 140434. PMID 12538551.
- ^ Torres AD, Rai AN, Hardiek ML (2000). "Mercury intoxication and arterial hypertension: report of two patients and review of the literature". Pediatrics. 105 (3): E34. doi:10.1542/peds.105.3.e34. PMID 10699136.