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Acrosin binding protein

From Wikipedia, the free encyclopedia
ACRBP
Identifiers
AliasesACRBP, CT23, OY-TES-1, SP32, acrosin binding protein
External IDsOMIM: 608352; MGI: 1859515; HomoloGene: 9641; GeneCards: ACRBP; OMA:ACRBP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032489

NM_001127340
NM_016845

RefSeq (protein)

NP_115878

NP_001120812
NP_058541

Location (UCSC)Chr 12: 6.64 – 6.65 MbChr 6: 125.03 – 125.04 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acrosin binding protein is a protein that in humans is encoded by the ACRBP gene. [5]

Function

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The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111644Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000072770Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Acrosin binding protein". Retrieved 2016-08-01.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.