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Avermitilol synthase

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Avermitilol synthase
Identifiers
EC no.4.2.3.96
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Avermitilol synthase (EC 4.2.3.96) is an enzyme with systematic name avermitilol hydrolase (cyclizing, avermitilol-forming).[1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O avermitilol + diphosphate

This enzyme requires Mg2+.

References

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  1. ^ Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE (July 2010). "Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol". Journal of the American Chemical Society. 132 (26): 8850–1. doi:10.1021/ja103087w. PMC 2904616. PMID 20536237.
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