CADPS

CADPS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WI1
Identifiers
Aliases	CADPS, CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator
External IDs	OMIM: 604667 MGI: 1350922 HomoloGene: 2755 GeneCards: CADPS
Gene location (Human) Chr. Chromosome 3 (human) Band 3p14.2 Start 62,398,346 bp End 62,875,416 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 A1 Start 12,372,563 bp End 12,823,079 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons Brodmann area 46 prefrontal cortex Brodmann area 9 cerebellar cortex cerebellar hemisphere superior frontal gyrus postcentral gyrus islet of Langerhans cingulate gyrus Top expressed in pontine nuclei medial vestibular nucleus dorsal tegmental nucleus mammillary body ventral tegmental area dorsomedial hypothalamic nucleus superior colliculus medial geniculate nucleus lateral geniculate nucleus lateral hypothalamus More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein kinase binding metal ion binding lipid binding Cellular component membrane cytoplasmic vesicle cytosol cell junction synapse cytoplasmic vesicle membrane presynapse glutamatergic synapse Biological process protein transport synaptic vesicle priming catecholamine secretion vesicle organization exocytosis synaptic vesicle exocytosis dense core granule exocytosis presynaptic dense core vesicle exocytosis positive regulation of exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8618 27062 Ensembl ENSG00000163618 ENSMUSG00000054423 UniProt Q9ULU8 Q80TJ1 RefSeq (mRNA) NM_003716 NM_183393 NM_183394 NM_001042617 NM_012061 NM_001359919 NM_001359920 NM_001359921 RefSeq (protein) NP_003707 NP_899630 NP_899631 NP_001036082 NP_036191 NP_001346848 NP_001346849 NP_001346850 Location (UCSC) Chr 3: 62.4 – 62.88 Mb Chr 14: 12.37 – 12.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.

External links

• Human CADPS genome location and CADPS gene details page in the UCSC Genome Browser.
• Human CAPS genome location and CAPS gene details page in the UCSC Genome Browser.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nishizaki T, Walent JH, Kowalchyk JA, Martin TF (1992). "A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C." J. Biol. Chem. 267 (33): 23972–81. doi:10.1016/S0021-9258(18)35932-5. PMID 1429734.
• Ann K, Kowalchyk JA, Loyet KM, Martin TF (1997). "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis". J. Biol. Chem. 272 (32): 19637–40. doi:10.1074/jbc.272.32.19637. PMID 9289490.
• Loyet KM, Kowalchyk JA, Chaudhary A, et al. (1998). "Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis". J. Biol. Chem. 273 (14): 8337–43. doi:10.1074/jbc.273.14.8337. PMID 9525942.
• Berwin B, Floor E, Martin TF (1998). "CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis". Neuron. 21 (1): 137–45. doi:10.1016/S0896-6273(00)80521-8. PMID 9697858.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family". Genomics. 81 (3): 279–91. doi:10.1016/S0888-7543(02)00040-X. PMID 12659812.
• Speidel D, Varoqueaux F, Enk C, et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function". J. Biol. Chem. 278 (52): 52802–9. doi:10.1074/jbc.M304727200. PMID 14530279.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS)". Biochem. Pharmacol. 69 (10): 1451–61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.