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CDC42EP2

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CDC42EP2
Identifiers
AliasesCDC42EP2, BORG1, CEP2, CDC42 effector protein 2
External IDsOMIM: 606132; MGI: 1929744; HomoloGene: 4933; GeneCards: CDC42EP2; OMA:CDC42EP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006779

NM_026772

RefSeq (protein)

NP_006770

NP_081048

Location (UCSC)Chr 11: 65.31 – 65.32 MbChr 19: 5.97 – 5.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cdc42 effector protein 2 is a protein that in humans is encoded by the CDC42EP2 gene.[5][6][7]

Function

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CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.[7]

Interactions

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CDC42EP2 has been shown to interact with CDC42[5][6] and RHOQ.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149798Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045664Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Joberty G, Perlungher RR, Macara IG (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Molecular and Cellular Biology. 19 (10): 6585–97. doi:10.1128/MCB.19.10.6585. PMC 84628. PMID 10490598.
  6. ^ a b Hirsch DS, Pirone DM, Burbelo PD (Jan 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". The Journal of Biological Chemistry. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
  7. ^ a b "Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2".
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Further reading

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