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CDIPT

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CDIPT
Identifiers
AliasesCDIPT, PIS, PIS1, CDP-diacylglycerol--inositol 3-phosphatidyltransferase
External IDsOMIM: 605893; MGI: 105491; HomoloGene: 7159; GeneCards: CDIPT; OMA:CDIPT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286585
NM_001286586
NM_006319
NM_145752

NM_026638
NM_001347656
NM_001379260

RefSeq (protein)

NP_001334585
NP_080914
NP_001366189

Location (UCSC)Chr 16: 29.86 – 29.86 MbChr 7: 126.58 – 126.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CDP-diacylglycerol—inositol 3-phosphatidyltransferase is an enzyme that in humans is encoded by the CDIPT gene.[5][6]

Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of multiple G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103502Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030682Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lykidis A, Jackson PD, Rock CO, Jackowski S (Jan 1998). "The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content". J Biol Chem. 272 (52): 33402–9. doi:10.1074/jbc.272.52.33402. PMID 9407135.
  6. ^ a b "Entrez Gene: CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)".
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Further reading

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