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CDP-glucose 4,6-dehydratase

From Wikipedia, the free encyclopedia
CDP-glucose 4,6-dehydratase
Identifiers
EC no.4.2.1.45
CAS no.37259-55-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PubMedarticles
NCBIproteins

The enzyme CDP-glucose 4,6-dehydratase (EC 4.2.1.45) catalyzes the chemical reaction

CDP-glucose CDP-4-dehydro-6-deoxy-D-glucose + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD+.

Nomenclature

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The systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include:

  • cytidine diphosphoglucose oxidoreductase, and
  • CDP-glucose 4,6-hydro-lyase.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1RKX and 1WVG.

References

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  • Hey AE, Elbein AD (1966). "Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 (22): 5473–8. doi:10.1016/S0021-9258(18)96454-9. PMID 4380946.
  • Matsuhashi S, Matsuhashi M, Brown JG, Strominger JL (1966). "Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. 3 Cytidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 241 (18): 4283–7. doi:10.1016/S0021-9258(18)99780-2. PMID 4288651.
  • Melo A, Elliott WH, Glaser L (1968). "The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase". J. Biol. Chem. 243 (7): 1467–74. doi:10.1016/S0021-9258(18)93566-0. PMID 4869560.