CDS1 (gene)

CDS1
Identifiers
Aliases	CDS1, CDS, CDP-diacylglycerol synthase 1, CDS 1
External IDs	OMIM: 603548; MGI: 1921846; HomoloGene: 68173; GeneCards: CDS1; OMA:CDS1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	84,651,334 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	101,971,724 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; secondary oocyte; ; caput epididymis; ; amniotic fluid; ; jejunal mucosa; ; mucosa of paranasal sinus; ; corpus epididymis; ; middle temporal gyrus; ; nasal epithelium; ; Brodmann area 23;
	Top expressed in
	transitional epithelium of urinary bladder; ; neural layer of retina; ; jejunum; ; nasal epithelium; ; olfactory epithelium; ; ileum; ; retinal pigment epithelium; ; vestibular membrane of cochlear duct; ; otolith organ; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity, transferring phosphorus-containing groups; nucleotidyltransferase activity; diacylglycerol cholinephosphotransferase activity; transferase activity; phosphatidate cytidylyltransferase activity;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum; endoplasmic reticulum membrane;
Biological process	phototransduction; phospholipid biosynthetic process; phosphatidylglycerol biosynthetic process; CDP-diacylglycerol biosynthetic process; lipid metabolism; signal transduction; phosphatidylinositol biosynthetic process; CDP-choline pathway;
	Sources:Amigo / QuickGO
Orthologs
	1040
	74596
	ENSG00000163624
	ENSMUSG00000029330
	Q92903
	P98191
	NM_001263
	NM_173370
	NP_001254
	NP_775546
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.^[5]^[6]^[7]

Function

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.^[8]^[9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163624 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (November 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID 9806839.
^ Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (March 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology. 16 (3): 281–9. doi:10.1089/dna.1997.16.281. PMID 9115637.
^ ^a ^b "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".
^ Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.
^ Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.

External links

Human CDS1 genome location and CDS1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163624 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029330 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9806839-5] Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (November 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID 9806839.

[pmid9115637-6] Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (March 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology. 16 (3): 281–9. doi:10.1089/dna.1997.16.281. PMID 9115637.

[entrez-7] "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".

[pmid15811335-8] Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.

[aachen-9] Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

References

Further reading

External links