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CLEC2D

From Wikipedia, the free encyclopedia

CLEC2D
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesCLEC2D, CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDsOMIM: 605659; HomoloGene: 137257; GeneCards: CLEC2D; OMA:CLEC2D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001004419
NP_001184246
NP_001184247
NP_001184248
NP_037401

n/a

Location (UCSC)Chr 12: 9.66 – 9.7 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.[3]

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined.[3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069493Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: CLEC2D C-type lectin domain family 2, member D".

Further reading

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