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CLK2

From Wikipedia, the free encyclopedia

CLK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCLK2, CDC like kinase 2
External IDsOMIM: 602989; MGI: 1098669; HomoloGene: 33303; GeneCards: CLK2; OMA:CLK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291
NM_001294338
NM_001294339
NM_003993
NM_001363704

NM_001163432
NM_007712

RefSeq (protein)

NP_001281267
NP_001281268
NP_003984
NP_001350633

NP_001156904
NP_031738

Location (UCSC)Chr 1: 155.26 – 155.28 MbChr 3: 89.07 – 89.08 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene.[5][6][7]

Function

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This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation.[7]

References

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  1. ^ a b c ENSG00000176444 GRCh38: Ensembl release 89: ENSG00000261893, ENSG00000176444Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068917Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hanes J, von der Kammer H, Klaudiny J, Scheit KH (Dec 1994). "Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases". Journal of Molecular Biology. 244 (5): 665–72. doi:10.1006/jmbi.1994.1763. PMID 7990150.
  6. ^ Talmadge CB, Finkernagel S, Sumegi J, Sciorra L, Rabinow L (Oct 1998). "Chromosomal mapping of three human LAMMER protein-kinase-encoding genes". Human Genetics. 103 (4): 523–4. doi:10.1007/s004390050861. PMID 9856501. S2CID 40593571.
  7. ^ a b "Entrez Gene: CLK2 CDC-like kinase 2".
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Further reading

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