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CLPTM1L

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CLPTM1L
Identifiers
AliasesCLPTM1L, CRR9, CLPTM1-like, CLPTM1 like
External IDsOMIM: 612585; MGI: 2442892; HomoloGene: 12767; GeneCards: CLPTM1L; OMA:CLPTM1L - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030782

NM_146047

RefSeq (protein)

NP_110409

NP_666159

Location (UCSC)Chr 5: 1.32 – 1.35 MbChr 13: 73.75 – 73.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene.[5][6] CRR9p is associated with cisplatin-induced apoptosis.[6] CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL.[7] Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.[8]

See also

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References

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  1. ^ a b c ENSG00000274811 GRCh38: Ensembl release 89: ENSG00000049656, ENSG00000274811Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021610Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: CLPTM1-like".
  6. ^ a b Yamamoto K, Okamoto A, Isonishi S, Ochiai K, Ohtake Y (Feb 2001). "A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis". Biochem Biophys Res Commun. 280 (4): 1148–54. doi:10.1006/bbrc.2001.4250. PMID 11162647.
  7. ^ James MA, Wen W, Wang Y, Byers LA, Heymach JV, Coombes KR, Girard L, Minna J, You M (2012). "Functional Characterization of CLPTM1L as a Lung". PLOS ONE. 7 (6): 63116. doi:10.1371/journal.pone.0036116. PMC 3366984. PMID 22675468.
  8. ^ James MA, Vikis HG, Tate E, Rymaszewski AL, et al. (2014). "CRR9/CLPTM1L regulates cell survival signaling and is required for Ras transformation and lung tumorigenesis". Cancer Res. 74 (4): 1116–27. doi:10.1158/0008-5472.CAN-13-1617. PMC 6005686. PMID 24366883.
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Further reading

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