COG3

COG3
Identifiers
Aliases	COG3, SEC34, component of oligomeric golgi complex 3
External IDs	OMIM: 606975 MGI: 2450151 HomoloGene: 5854 GeneCards: COG3
Gene location (Human)
Chr.	Chromosome 13 (human)
End	45,536,701 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	75,991,998 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right lobe of liver; ; Achilles tendon; ; rectum; ; monocyte; ; pancreatic ductal cell; ; right adrenal gland; ; bone marrow cells; ; minor salivary glands; ; islet of Langerhans;
	Top expressed in
	otolith organ; ; utricle; ; Paneth cell; ; cumulus cell; ; seminal vesicula; ; hand; ; ciliary body; ; medullary collecting duct; ; lacrimal gland; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Golgi membrane; cis-Golgi network; membrane; Golgi apparatus; Golgi cisterna membrane; Golgi transport complex; trans-Golgi network membrane; cytosol; plasma membrane;
Biological process	protein glycosylation; intracellular protein transport; protein stabilization; intra-Golgi vesicle-mediated transport; endoplasmic reticulum to Golgi vesicle-mediated transport; protein transport; Golgi organization; protein localization to organelle; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;
	Sources:Amigo / QuickGO
Orthologs
	83548
	338337
	ENSG00000136152
	ENSMUSG00000034893
	Q96JB2
	Q8CI04
	NM_001204476; NM_031431
	NM_177381
	NP_113619
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.^[5]^[6]

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.^[6]

Interactions[edit]

COG3 has been shown to interact with COG2^[7] and COG1.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136152 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034893 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (April 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". The Journal of Cell Biology. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
^ ^a ^b "Entrez Gene: COG3 component of oligomeric golgi complex 3".
^ ^a ^b Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.

External links[edit]

Human COG3 genome location and COG3 gene details page in the UCSC Genome Browser.

Further reading[edit]

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kim DW, Sacher M, Scarpa A, Quinn AM, Ferro-Novick S (October 1999). "High-copy suppressor analysis reveals a physical interaction between Sec34p and Sec35p, a protein implicated in vesicle docking". Molecular Biology of the Cell. 10 (10): 3317–29. doi:10.1091/mbc.10.10.3317. PMC 25597. PMID 10512869.
VanRheenen SM, Cao X, Sapperstein SK, Chiang EC, Lupashin VV, Barlowe C, Waters MG (November 1999). "Sec34p, a protein required for vesicle tethering to the yeast Golgi apparatus, is in a complex with Sec35p". The Journal of Cell Biology. 147 (4): 729–42. doi:10.1083/jcb.147.4.729. PMC 2156162. PMID 10562277.
Suvorova ES, Kurten RC, Lupashin VV (June 2001). "Identification of a human orthologue of Sec34p as a component of the cis-Golgi vesicle tethering machinery". The Journal of Biological Chemistry. 276 (25): 22810–8. doi:10.1074/jbc.M011624200. PMID 11292827.
Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Loh E, Hong W (June 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". The Journal of Biological Chemistry. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. PMID 15047703.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136152 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034893 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11980916-5] Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (April 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". The Journal of Cell Biology. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.

[entrez-6] "Entrez Gene: COG3 component of oligomeric golgi complex 3".

[pmid11929878-7] Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.

[1]

[2]

[3]

[4]

[5]

[6]

[7]