Jump to content

COX7A1

From Wikipedia, the free encyclopedia
COX7A1
Identifiers
AliasesCOX7A1, COX7A, COX7AH, COX7AM, cytochrome c oxidase subunit 7A1
External IDsOMIM: 123995; MGI: 1316714; HomoloGene: 48051; GeneCards: COX7A1; OMA:COX7A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001864

NM_009944

RefSeq (protein)

NP_001855

NP_034074

Location (UCSC)Chr 19: 36.15 – 36.15 MbChr 7: 29.88 – 29.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene.[5][6][7]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (muscle isoform) of subunit VIIa and the polypeptide 1 is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000161281Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074218Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Arnaudo E, Hirano M, Seelan RS, Milatovich A, Hsieh CL, Fabrizi GM, Grossman LI, Francke U, Schon EA (Nov 1992). "Tissue-specific expression and chromosome assignment of genes specifying two isoforms of subunit VIIa of human cytochrome c oxidase". Gene. 119 (2): 299–305. doi:10.1016/0378-1119(92)90287-Y. PMID 1327965.
  6. ^ Fabrizi GM, Rizzuto R, Nakase H, Mita S, Lomax MI, Grossman LI, Schon EA (Oct 1989). "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase". Nucleic Acids Res. 17 (17): 7107. doi:10.1093/nar/17.17.7107. PMC 318441. PMID 2550906.
  7. ^ a b "Entrez Gene: COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)".
[edit]

Further reading

[edit]