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CPZ (gene)

From Wikipedia, the free encyclopedia
CPZ
Identifiers
AliasesCPZ, carboxypeptidase Z
External IDsOMIM: 603105; MGI: 88487; HomoloGene: 2709; GeneCards: CPZ; OMA:CPZ - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003652
NM_001014447
NM_001014448

NM_153107

RefSeq (protein)

NP_001014447
NP_001014448
NP_003643

NP_694747

Location (UCSC)Chr 4: 8.59 – 8.62 MbChr 5: 35.66 – 35.68 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase Z is an enzyme that in humans is encoded by the CPZ gene.[5][6]

This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109625Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036596Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Song L, Fricker LD (May 1997). "Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase". J Biol Chem. 272 (16): 10543–50. doi:10.1074/jbc.272.16.10543. PMID 9099699.
  6. ^ a b "Entrez Gene: CPZ carboxypeptidase Z".
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Further reading

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