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Carbamoyl-serine ammonia-lyase

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carbamoyl-serine ammonia-lyase
Identifiers
EC no.4.3.1.13
CAS no.52227-64-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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Gene OntologyAmiGO / QuickGO
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The enzyme carbamoyl-serine ammonia-lyase (EC 4.3.1.13) catalyzes the chemical reaction

O-carbamoyl-L-serine + H2O = pyruvate + 2 NH3 + CO2 (overall reaction)
(1a) O-carbamoyl-L-serine = CO2 + NH3 + 2-aminoprop-2-enoate
(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous)
(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is O-carbamoyl-L-serine ammonia-lyase (decarboxylating; pyruvate-forming). Other names in common use include O-carbamoyl-L-serine deaminase, carbamoylserine deaminase, and O-carbamoyl-L-serine ammonia-lyase (pyruvate-forming). It employs one cofactor, pyridoxal phosphate.

References

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  • Copper AJ, Meister A (1973). "Enzymatic conversion of O-carbamyl-L-serine to pyruvate and ammonia". Biochem. Biophys. Res. Commun. 55 (3): 780–7. doi:10.1016/0006-291X(73)91212-6. PMID 4761084.