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Carboxypeptidase A2

From Wikipedia, the free encyclopedia
CPA2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCPA2, carboxypeptidase A2
External IDsOMIM: 600688; MGI: 3617840; HomoloGene: 37541; GeneCards: CPA2; OMA:CPA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001869

NM_001024698

RefSeq (protein)

NP_001860

NP_001019869

Location (UCSC)Chr 7: 130.27 – 130.29 MbChr 6: 30.54 – 30.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxypeptidase A2 is an enzyme that in humans is encoded by the CPA2 gene.[5][6][7]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. The A2 form of pancreatic procarboxypeptidase acts on aromatic C-terminal residues[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158516Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071553Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Catasus L, Vendrell J, Aviles FX, Carreira S, Puigserver A, Billeter M (Apr 1995). "The sequence and conformation of human pancreatic procarboxypeptidase A2. cDNA cloning, sequence analysis, and three-dimensional model". J Biol Chem. 270 (12): 6651–7. doi:10.1074/jbc.270.12.6651. PMID 7896805.
  6. ^ Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (Aug 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
  7. ^ a b "Entrez Gene: CPA2 carboxypeptidase A2 (pancreatic)".

Further reading

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[edit]
  • The MEROPS online database for peptidases and their inhibitors: M14.002
  • Overview of all the structural information available in the PDB for UniProt: P48052 (Human Carboxypeptidase A2) at the PDBe-KB.