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Chromosome 1 open reading frame 162

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C1orf162
Identifiers
AliasesC1orf162, chromosome 1 open reading frame 162
External IDsMGI: 3588284; HomoloGene: 45482; GeneCards: C1orf162; OMA:C1orf162 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300834
NM_001300835
NM_174896

NM_001033780

RefSeq (protein)

NP_001287763
NP_001287764
NP_777556

NP_001028952

Location (UCSC)Chr 1: 111.47 – 111.48 MbChr 3: 105.83 – 105.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chromosome 1 open reading frame 162 is a protein that in humans is encoded by the C1orf162 gene. It has been found to be hypomethylated in instances of gastric cancer. [5]

Gene

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The gene is located at p13.2 on chromosome 1 in humans and contains 8 exons.[6] It is 11,026 bases long and is oriented on the plus strand.[7]

Illustration of genomic context of C1orf162.

mRNA

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Three transcript variants have been identified. Isoform 1 is the longest transcript and encodes the longest isoform. Isoform 2 uses an alternate in-frame splice site and is shorter than isoform 1. Isoform 3 lacks an alternate in-frame exon and is shorter compared to isoform 1.[8] There are six stem loops in the 5' untranslated region and five stem loops in the 3' untranslated region.[9]

Protein

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The predicted molecular weight of the protein C1orf162 is 16.9 kdal. Its isoelectric point is approximately 9.2 in mammals.[10] A single transmembrane region is conserved across species.[11] The protein is predicted to localize mainly in the nucleus.[12] The protein is predicted to be myristoylated.[13]

Illustration of transmembrane region of C1orf162.

Expression

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C1orf162 is not ubiquitously expressed in humans. According to microarray-assessed tissue expression patterns, C1orf162 is most highly expressed in bone marrow, lung, fetal liver, lymph node, spleen, and thymus in normal human tissues.[14] Staining of normal tissues has found high levels of RNA expression in bone marrow, lymph node, spleen, and lung tissue, which coincides with microarray-assessed expression patterns.[15]

Expression of C1orf162 in normal human tissues.

Clinical Significance

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One study found the protein to be one of three hypomethylated proteins in instances of gastric cancer.[16]

Homology

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The gene has no known paralogs. Orthologs have been noted in many mammal species in addition to a few birds and reptiles. The transmembrane region of the protein is highly conserved across species. No orthologs have been identified in fish, insects, or prokaryotes.[17]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143110Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074342Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Chromosome 1 open reading frame 162". Retrieved 2016-05-09.
  6. ^ "NCBI GenBank". 19 March 2015.
  7. ^ "GeneCards".
  8. ^ "NCBI Gene".
  9. ^ "M-fold Analysis".
  10. ^ "SDSC Biology Workbench".[permanent dead link]
  11. ^ "CCTOP".
  12. ^ "PSORTII".
  13. ^ "Myristoylator Prediction Program".[permanent dead link]
  14. ^ "NCBI GEO".
  15. ^ "Protein Atlas".
  16. ^ Choi B, Han TS, Lee JY, Lee S, Kong SH, Lee HJ, Kim YJ, Yang HK (2013). "Gene methylation as a novel marker in gastric cancer". Cancer Research. 8 (73): 643. doi:10.1158/1538-7445.AM2013-643.
  17. ^ "NCBI Gene Orthologs".

Further reading

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