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DACH2

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DACH2
Identifiers
AliasesDACH2, dachshund family transcription factor 2
External IDsOMIM: 300608; MGI: 1890446; HomoloGene: 33472; GeneCards: DACH2; OMA:DACH2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001139514
NM_001139515
NM_053281

NM_001142570
NM_001289732
NM_001289733
NM_001289734
NM_033605

RefSeq (protein)

NP_001132986
NP_001132987
NP_444511

NP_001136042
NP_001276661
NP_001276662
NP_001276663
NP_291083

Location (UCSC)Chr X: 86.15 – 86.83 MbChr X: 112.21 – 112.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.[5]

Function

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This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126733Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025592Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Multiple transcript variants encoding different isoforms have been found for this gene. "Entrez Gene: Dachshund homolog 2 (Drosophila)". Retrieved 2012-04-15.

Further reading

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