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DCAF15

From Wikipedia, the free encyclopedia
DCAF15
Identifiers
AliasesDCAF15, C19orf72, DDB1 and CUL4 associated factor 15
External IDsMGI: 2684420; HomoloGene: 18182; GeneCards: DCAF15; OMA:DCAF15 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_138353

NM_172502
NM_001357322

RefSeq (protein)

NP_612362

NP_766090
NP_001344251

Location (UCSC)Chr 19: 13.95 – 13.96 MbChr 8: 84.82 – 84.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DDB1 and CUL4 associated factor 15 is a protein that in humans is encoded by the DCAF15 gene.[5]

DCAF15 forms a complex with CUL4A or CUL4B that has E3 ubiquitin ligase activity and is responsible for the proteasome degradation of certain proteins.[6]

References

[edit]
  1. ^ a b c ENSG00000288453 GRCh38: Ensembl release 89: ENSG00000132017, ENSG00000288453Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037103Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DDB1 and CUL4 associated factor 15".
  6. ^ Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D (April 2017). "Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15". Science. 356 (6336): eaal3755. doi:10.1126/science.aal3755. PMID 28302793. S2CID 3885214.