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DCTN3

From Wikipedia, the free encyclopedia
DCTN3
Identifiers
AliasesDCTN3, DCTN-22, DCTN22, dynactin subunit 3
External IDsOMIM: 607387; MGI: 1859251; HomoloGene: 5233; GeneCards: DCTN3; OMA:DCTN3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024348
NM_001281425
NM_001281426
NM_001281427
NM_007234

NM_001159565
NM_016890

RefSeq (protein)

NP_001268354
NP_001268355
NP_001268356
NP_009165
NP_077324

NP_001153037
NP_058586

Location (UCSC)Chr 9: 34.61 – 34.62 MbChr 4: 41.71 – 41.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dynactin subunit 3 is a protein that in humans is encoded by the DCTN3 gene.[5][6][7]

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing of this gene generates 2 transcript variants.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000137100Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028447Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Karki S, LaMonte B, Holzbaur EL (Sep 1998). "Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells". J Cell Biol. 142 (4): 1023–34. doi:10.1083/jcb.142.4.1023. PMC 2132867. PMID 9722614.
  6. ^ Mills DR, Jackson CL (Apr 2001). "Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping". Cytogenet Cell Genet. 92 (1–2): 166. doi:10.1159/000056892. PMID 11306820. S2CID 84893310.
  7. ^ a b "Entrez Gene: DCTN3 dynactin 3 (p22)".

Further reading

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