Jump to content

DCUN1D1

From Wikipedia, the free encyclopedia
DCUN1D1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDCUN1D1, DCNL1, DCUN1L1, RP42, SCCRO, SCRO, Tes3, defective in cullin neddylation 1 domain containing 1
External IDsOMIM: 605905; MGI: 2150386; HomoloGene: 10773; GeneCards: DCUN1D1; OMA:DCUN1D1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001308101
NM_020640

NM_001205361
NM_001205362
NM_033623

RefSeq (protein)

NP_001295030
NP_065691

NP_001192290
NP_001192291
NP_296372

Location (UCSC)Chr 3: 182.94 – 182.99 MbChr 3: 35.95 – 35.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DCN1-like protein 1 is a protein that in humans is encoded by the DCUN1D1 gene.[5][6][7]

DCUN1D1 is amplified in several cancer types, including squamous cell cancers, and may act as an oncogenic driver in cancer cells.[8][9][10]

Interactions

[edit]

DCUN1D1 has been shown to interact with:

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000043093Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027708Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mas C, Bourgeois F, Bulfone A, Levacher B, Mugnier C, Simonneau M (Apr 2000). "Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16". Genomics. 65 (1): 70–4. doi:10.1006/geno.2000.6126. PMID 10777668.
  6. ^ Kurz T, Ozlü N, Rudolf F, O'Rourke SM, Luke B, Hofmann K, Hyman AA, Bowerman B, Peter M (Jun 2005). "The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae". Nature. 435 (7046): 1257–61. Bibcode:2005Natur.435.1257K. doi:10.1038/nature03662. PMID 15988528. S2CID 4328225.
  7. ^ "Entrez Gene: DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)".
  8. ^ Broderick SR, Golas BJ, Pham D, Towe CW, Talbot SG, Kaufman A, Bains S, Huryn LA, Yonekawa Y, Carlson D, Hambardzumyan D, Ramanathan Y, Singh B (Jun 2010). "SCCRO promotes glioma formation and malignant progression in mice". Neoplasia. 12 (6): 476–84. doi:10.1593/neo.10202. PMC 2887088. PMID 20563250.
  9. ^ Sarkaria I, O-charoenrat P, Talbot SG, Reddy PG, Ngai I, Maghami E, Patel KN, Lee B, Yonekawa Y, Dudas M, Kaufman A, Ryan R, Ghossein R, Rao PH, Stoffel A, Ramanathan Y, Singh B (Oct 2006). "Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas". Cancer Research. 66 (19): 9437–44. doi:10.1158/0008-5472.CAN-06-2074. PMID 17018598.
  10. ^ Chen Y, McGee J, Chen X, Doman TN, Gong X, Zhang Y, Hamm N, Ma X, Higgs RE, Bhagwat SV, Buchanan S, Peng SB, Staschke KA, Yadav V, Yue Y, Kouros-Mehr H (2014). "Identification of druggable cancer driver genes amplified across TCGA datasets". PLOS ONE. 9 (5): e98293. Bibcode:2014PLoSO...998293C. doi:10.1371/journal.pone.0098293. PMC 4038530. PMID 24874471.
  11. ^ a b c d e Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B (Nov 2008). "SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation". The Journal of Biological Chemistry. 283 (48): 33211–20. doi:10.1074/jbc.M804440200. PMC 2586271. PMID 18826954.

Further reading

[edit]