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DDO (gene)

From Wikipedia, the free encyclopedia
DDO
Identifiers
AliasesDDO, Ddo, 5330420D20Rik, 5730402C02Rik, AI467244, DASOX, DDO-1, DDO-2, D-aspartate oxidase
External IDsOMIM: 124450; MGI: 1925528; HomoloGene: 101531; GeneCards: DDO; OMA:DDO - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003649
NM_004032

NM_027442
NM_001316716
NM_001316717
NM_001316718
NM_001316719

RefSeq (protein)

NP_001303645
NP_001303646
NP_001303647
NP_001303648
NP_081718

Location (UCSC)Chr 6: 110.39 – 110.42 MbChr 10: 40.51 – 40.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

D-aspartate oxidase is an enzyme that is encoded by the DDO gene.[5][6]

The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two (or four, according to Q99489) transcript variants encoding different isoforms have been found for this gene.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000203797Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063428Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Setoyama C, Miura R (Jul 1997). "Structural and functional characterization of the human brain D-aspartate oxidase". J Biochem. 121 (4): 798–803. doi:10.1093/oxfordjournals.jbchem.a021655. PMID 9163533.
  6. ^ a b "Entrez Gene: DDO D-aspartate oxidase".

Further reading

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