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DNA ligase (NAD+)

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DNA ligase (NAD+)
Identifiers
EC no.6.5.1.2
CAS no.37259-52-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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DNA ligase (NAD+) (EC 6.5.1.2, polydeoxyribonucleotide synthase (NAD+), polynucleotide ligase (NAD+), DNA repair enzyme, DNA joinase, polynucleotide synthetase (nicotinamide adenine dinucleotide), deoxyribonucleic-joining enzyme, deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic acid ligase, polynucleotide synthetase, deoxyribonucleic acid joinase, DNA-joining enzyme, polynucleotide ligase (nicotinamide adenine dinucleotide)) is an enzyme with systematic name poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming).[1] This enzyme catalyses the following chemical reaction

NAD+ + (deoxyribonucleotide)n + (deoxyribonucleotide)m AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)n+m

Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA.

See also

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References

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  1. ^ Zimmerman SB, Little JW, Oshinsky CK, Gellert M (June 1967). "Enzymatic joining of DNA strands: a novel reaction of diphosphopyridine nucleotide". Proceedings of the National Academy of Sciences of the United States of America. 57 (6): 1841–8. Bibcode:1967PNAS...57.1841Z. doi:10.1073/pnas.57.6.1841. PMC 224555. PMID 4291949.
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