DOC2A

DOC2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4MJJ
Identifiers
Aliases	DOC2A, Doc2, double C2 domain alpha
External IDs	OMIM: 604567 MGI: 109446 HomoloGene: 2657 GeneCards: DOC2A
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,023,270 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,451,877 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; prefrontal cortex; ; right uterine tube; ; amygdala; ; superior frontal gyrus; ; hippocampus proper; ; caudate nucleus; ; middle temporal gyrus; ; Brodmann area 46; ; nucleus accumbens;
	Top expressed in
	ventromedial nucleus; ; cingulate gyrus; ; primary motor cortex; ; motor neuron; ; piriform cortex; ; barrel cortex; ; prefrontal cortex; ; paraventricular nucleus of hypothalamus; ; subiculum; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium-dependent phospholipid binding; clathrin binding; calcium ion binding; syntaxin binding; protein binding;
Cellular component	neuron projection; lysosome; synapse; synaptic vesicle membrane; membrane; cytoplasmic vesicle; plasma membrane; nucleus; nucleolus; cell junction; exocytic vesicle; extrinsic component of synaptic vesicle membrane;
Biological process	nervous system development; regulation of calcium ion-dependent exocytosis; synaptic vesicle exocytosis; exocytosis; chemical synaptic transmission; calcium ion-regulated exocytosis of neurotransmitter; vesicle fusion; spontaneous neurotransmitter secretion;
	Sources:Amigo / QuickGO
Orthologs
	8448
	13446
	ENSG00000149927
	ENSMUSG00000052301
	Q14183
	Q7TNF0
	NM_001282062; NM_001282063; NM_001282068; NM_003586
	NM_010069; NM_001368355; NM_001368356; NM_001368357; NM_001368358
	NP_001268991; NP_001268992; NP_001268997; NP_003577
	NP_034199; NP_001355284; NP_001355285; NP_001355286; NP_001355287
	Wikidata
View/Edit Human	View/Edit Mouse

Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene.^[5]^[6]^[7]

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release.^[7]

Interactions[edit]

DOC2A has been shown to interact with UNC13B^[6]^[8] and UNC13A.^[9]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149927 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052301 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.
^ ^a ^b Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. Bibcode:1998PNAS...9511418M. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.
^ ^a ^b "Entrez Gene: DOC2A double C2-like domains, alpha".
^ Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.
^ "Protein unc-13 homolog A". UniProt.

Further reading[edit]

Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of an isoform of Doc2 having two C2-like domains". Biochem. Biophys. Res. Commun. 217 (3): 1053–61. doi:10.1006/bbrc.1995.2876. PMID 8554557.
Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (March 1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738. S2CID 17948539.
Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y (November 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065–8. doi:10.1074/jbc.273.46.30065. PMID 9804756.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149927 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052301 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7826360-5] Orita S, Sasaki T, Naito A, Komuro R, Ohtsuka T, Maeda M, Suzuki H, Igarashi H, Takai Y (Feb 1995). "Doc2: a novel brain protein having two repeated C2-like domains". Biochem Biophys Res Commun. 206 (2): 439–48. doi:10.1006/bbrc.1995.1062. PMID 7826360.

[pmid9736751-6] Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y (Oct 1998). "Role of the Doc2α–Munc13–1 interaction in the neurotransmitter release process". Proc Natl Acad Sci U S A. 95 (19): 11418–22. Bibcode:1998PNAS...9511418M. doi:10.1073/pnas.95.19.11418. PMC 21657. PMID 9736751.

[entrez-7] "Entrez Gene: DOC2A double C2-like domains, alpha".

[pmid9195900-8] Orita S, Naito A, Sakaguchi G, Maeda M, Igarashi H, Sasaki T, Takai Y (June 1997). "Physical and functional interactions of Doc2 and Munc13 in Ca2+-dependent exocytotic machinery". J. Biol. Chem. 272 (26): 16081–4. doi:10.1074/jbc.272.26.16081. PMID 9195900.

[9] "Protein unc-13 homolog A". UniProt.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]