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DPP7

From Wikipedia, the free encyclopedia

DPP7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDPP7, DPP2, DPPII, QPP, dipeptidyl peptidase 7
External IDsOMIM: 610537; MGI: 1933213; HomoloGene: 22748; GeneCards: DPP7; OMA:DPP7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013379

NM_031843

RefSeq (protein)

NP_037511

NP_114031

Location (UCSC)Chr 9: 137.11 – 137.12 MbChr 2: 25.24 – 25.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.[5][6][7]

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolyl carboxypeptidase and is active at both acidic and neutral pH.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176978Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026958Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol. 163 (6): 3092–9. doi:10.4049/jimmunol.163.6.3092. PMID 10477574.
  6. ^ Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J. 353 (Pt 2): 283–90. doi:10.1042/0264-6021:3530283. PMC 1221570. PMID 11139392.
  7. ^ a b "Entrez Gene: DPP7 dipeptidyl-peptidase 7".

Further reading

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