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dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase

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DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase
Identifiers
EC no.2.1.1.234
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IntEnzIntEnz view
BRENDABRENDA entry
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DTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose N,N-dimethyltransferase (EC 2.1.1.234, DesVI) is an enzyme with systematic name S-adenosyl-L-methionine:dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 3-N,N-dimethyltransferase.[1][2] This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose 2 S-adenosyl-L-homocysteine + dTDP-3-dimethylamino-3,4,6-trideoxy-alpha-D-glucopyranose

The enzyme is involved in the biosynthesis of desosamine.

References

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  1. ^ Chen H, Yamase H, Murakami K, Chang CW, Zhao L, Zhao Z, Liu HW (July 2002). "Expression, purification, and characterization of two N,N-dimethyltransferases, tylM1 and desVI, involved in the biosynthesis of mycaminose and desosamine". Biochemistry. 41 (29): 9165–83. doi:10.1021/bi020245j. PMID 12119032.
  2. ^ Burgie ES, Holden HM (April 2008). "Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis". Biochemistry. 47 (13): 3982–8. doi:10.1021/bi800063j. PMID 18327916.
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