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DTX1

From Wikipedia, the free encyclopedia
DTX1
Identifiers
AliasesDTX1, hDx-1, deltex 1, deltex E3 ubiquitin ligase 1, RNF140
External IDsOMIM: 602582; MGI: 1352744; HomoloGene: 74522; GeneCards: DTX1; OMA:DTX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004416

NM_008052

RefSeq (protein)

NP_004407

NP_032078

Location (UCSC)Chr 12: 113.06 – 113.1 MbChr 5: 120.82 – 120.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.[5][6]

Function

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Studies in Drosophila have identified this gene as encoding a positive regulator of the notch signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.[6]

Interactions

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DTX1 has been shown to interact with EP300.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135144Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029603Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S (May 1998). "Human deltex is a conserved regulator of Notch signalling". Nature Genetics. 19 (1): 74–8. doi:10.1038/ng0598-74. PMID 9590294. S2CID 6812613.
  6. ^ a b "Entrez Gene: DTX1 deltex homolog 1 (Drosophila)".
  7. ^ Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (Nov 2001). "Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor". The Journal of Biological Chemistry. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.

Further reading

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