Jump to content

Dimethylamine-corrinoid protein Co-methyltransferase

From Wikipedia, the free encyclopedia
Dimethylamine-corrinoid protein Co-methyltransferase
Identifiers
EC no.2.1.1.249
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Dimethylamine-corrinoid protein Co-methyltransferase (EC 2.1.1.249, mtbB (gene), dimethylamine methyltransferase) is an enzyme with systematic name dimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

dimethylamine + [Co(I) dimethylamine-specific corrinoid protein] [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine

This enzyme is involved in methanogenesis from dimethylamine.

References

[edit]
  1. ^ Wassenaar RW, Keltjens JT, van der Drift C, Vogels GD (May 1998). "Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro". European Journal of Biochemistry. 253 (3): 692–7. doi:10.1046/j.1432-1327.1998.2530692.x. PMID 9654067.
  2. ^ Ferguson DJ, Gorlatova N, Grahame DA, Krzycki JA (September 2000). "Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri". The Journal of Biological Chemistry. 275 (37): 29053–60. doi:10.1074/jbc.m910218199. PMID 10852929.
  3. ^ Krzycki JA (October 2004). "Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases". Current Opinion in Chemical Biology. 8 (5): 484–91. doi:10.1016/j.cbpa.2004.08.012. PMID 15450490.
[edit]