Dorothea Fiedler

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Dorothea Fiedler
Dorothea Fiedler
Prof. Dr. Dorothea Fiedler
Alma materUniversity of Würzburg (Diplom 2001)
University of California at Berkeley (PhD 2005)
Scientific career
InstitutionsPrinceton University, Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Doctoral advisorsKenneth N. Raymond, Robert G. Bergman
Other academic advisorsKevan M. Shokat

Dorothea Fiedler is a chemical biologist and also the first female director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Leibniz Research Institute for Molecular Pharmacology, FMP) in Berlin, Germany.

Early life and education[edit]

Fiedler grew up in Hamburg.[1] She studied inorganic chemistry at the University of Würzburg,[2] then carried out doctorate research on organometallic chemistry at the University of California at Berkeley.[1][3]

Research and career[edit]

Although her PhD research focussed on organometallic chemistry[4][5] including host-guest systems and applications to catalysis,[6][7] Fiedler became interested in cellular signal transduction pathways during her postdoctoral research at the University of California, San Francisco.[1][8] She started her independent career as an assistant professor at Princeton University in 2010.[9] Her research focuses on the synthesis and signalling roles of inositol phosphates,[10] in particular, those with a pyrophosphate functionality,[11][12][13][14] which has relevance to cellular signalling and cancer biology.[15][16]

In 2015, Fiedler became the director of the Leibniz-Forschungsinstitut für Molekulare Pharmakologie as well as a professor of chemistry at the Humboldt University of Berlin.[17] She continues developing her research focus on the synthesis and signalling roles of protein modifications involving pyrophosphates,[18][19] as well as building collaborations on biological chemistry and catalysis.[20]

Funding, service, and awards[edit]

Fiedler has received a New Innovator Award totalling over $2 million from the NIH in 2013.[21] She also received funding from the Sidney Kimmel Foundation for Cancer Research[22][23] and the Rita Allen Foundation.[24] During her postdoctoral research, she received the Ernst Schering Foundation Postdoctoral Fellowship, was on the Fastrack Program of the Robert Bosch Foundation, and obtained an NIH Pathway to Independence Award.[25]

Fiedler is an invited speaker at the EMBO conference on Chemical Biology 2016[26] and at the International Symposium on Bioorganic Chemistry in 2017.[27]

Fiedler is one of the local organizers of the 42nd National Organic Chemistry Symposium by the organic division of the American Chemical Society in 2011.[28]

References[edit]

  1. ^ a b c "FMP Berlin: Dorothea Fiedler is a new director at the FMP". www.leibniz-fmp.de. 2015-07-14. Retrieved 2019-03-07.[permanent dead link]
  2. ^ "Dorothea Fiedler, Chemie, Humboldt-Universität Berlin". www.uni-wuerzburg.de (in German). Retrieved 2019-03-17.[permanent dead link]
  3. ^ "Dorothea Fiedler | Gesellschaft Deutscher Chemiker e.V." www.gdch.de. Retrieved 2023-08-26.
  4. ^ Fiedler, Dorothea; Pagliero, Daniela; Brumaghim, Julia L.; Bergman, Robert G.; Raymond, Kenneth N. (2004-01-15). "Encapsulation of Cationic Ruthenium Complexes into a Chiral Self-Assembled Cage". Inorganic Chemistry. 43 (3): 846–848. doi:10.1021/ic035105s. ISSN 0020-1669. PMID 14753801.
  5. ^ Fiedler, Dorothea; Leung, Dennis H.; Bergman, Robert G.; Raymond, Kenneth N. (2004-03-06). "Enantioselective Guest Binding and Dynamic Resolution of Cationic Ruthenium Complexes by a Chiral Metal−Ligand Assembly". Journal of the American Chemical Society. 126 (12): 3674–3675. doi:10.1021/ja039225a. ISSN 0002-7863. PMID 15038695.
  6. ^ Fiedler, Dorothea; van Halbeek, Herman; Bergman, Robert G.; Raymond, Kenneth N. (2006-07-19). "Supramolecular Catalysis of Unimolecular Rearrangements: Substrate Scope and Mechanistic Insights". Journal of the American Chemical Society. 128 (31): 10240–10252. doi:10.1021/ja062329b. ISSN 0002-7863. PMID 16881654.
  7. ^ Fiedler, Dorothea; Leung, Dennis H.; Bergman, Robert G.; Raymond, Kenneth N. (2005-04-01). "Selective Molecular Recognition, C−H Bond Activation, and Catalysis in Nanoscale Reaction Vessels". Accounts of Chemical Research. 38 (4): 349–358. CiteSeerX 10.1.1.455.402. doi:10.1021/ar040152p. ISSN 0001-4842. PMID 15835881. S2CID 2954569.
  8. ^ Fiedler, Dorothea; Braberg, Hannes; Mehta, Monika; Chechik, Gal; Cagney, Gerard; Mukherjee, Paromita; Silva, Andrea C.; Shales, Michael; Collins, Sean R. (2009-03-05). "Functional Organization of the S. cerevisiae Phosphorylation Network". Cell. 136 (5): 952–963. doi:10.1016/j.cell.2008.12.039. PMC 2856666. PMID 19269370.
  9. ^ Princeton Alumni Weekly. princeton alumni weekly. 2009-06-10.
  10. ^ "Research - Fiedler Group". www.princeton.edu. Archived from the original on 2015-09-06. Retrieved 2019-03-17.
  11. ^ Campbell, Meghan (2015-02-05). "Lost in Post-Translation :: ChemViews Magazine :: ChemistryViews". www.chemistryviews.org. Retrieved 2019-03-17.
  12. ^ Wu, Mingxuan; Dul, Barbara E.; Trevisan, Alexandra J.; Fiedler, Dorothea (2013). "Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers". Chem. Sci. 4 (1): 405–410. doi:10.1039/C2SC21553E. ISSN 2041-6520. PMC 3558982. PMID 23378892.
  13. ^ Williams, Florence J.; Fiedler, Dorothea (2015-09-18). "A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins". ACS Chemical Biology. 10 (9): 1958–1963. doi:10.1021/acschembio.5b00256. ISSN 1554-8929. PMID 26061479.
  14. ^ Marmelstein, Alan M.; Yates, Lisa M.; Conway, John H.; Fiedler, Dorothea (2014-01-08). "Chemical Pyrophosphorylation of Functionally Diverse Peptides". Journal of the American Chemical Society. 136 (1): 108–111. doi:10.1021/ja411737c. ISSN 0002-7863. PMC 3992712. PMID 24350643.
  15. ^ Shears, Stephen B. (2014-10-05). "Inositol pyrophosphates: Why so many phosphates?". Advances in Biological Regulation. 57: 203–216. doi:10.1016/j.jbior.2014.09.015. PMC 4291286. PMID 25453220.
  16. ^ Shah, Akruti; Ganguli, Shubhra; Sen, Jayraj; Bhandari, Rashna (2017-02-28). "Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules". Journal of the Indian Institute of Science. 97 (1): 23–40. doi:10.1007/s41745-016-0011-3. ISSN 0970-4140. PMC 7081659. PMID 32214696.
  17. ^ "Humboldt-Universität zu Berlin - Dorothea Fiedler". agnes.hu-berlin.de. Retrieved 2019-03-17.
  18. ^ Yates, Lisa M.; Fiedler, Dorothea (2016-04-15). "A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins". ACS Chemical Biology. 11 (4): 1066–1073. doi:10.1021/acschembio.5b00972. ISSN 1554-8929. PMID 26760216.
  19. ^ Marmelstein, Alan M.; Morgan, Jeremy A. M.; Penkert, Martin; Rogerson, Daniel T.; Chin, Jason W.; Krause, Eberhard; Fiedler, Dorothea (2018). "Pyrophosphorylation via selective phosphoprotein derivatization". Chemical Science. 9 (27): 5929–5936. doi:10.1039/C8SC01233D. ISSN 2041-6520. PMC 6050540. PMID 30079207.
  20. ^ "UniSysCat: Signal-controlled multicomponent catalysis". www.unisyscat.tu-berlin.de. Archived from the original on 2021-04-13. Retrieved 2019-03-17.
  21. ^ Fiedler, Dorothea (2013). "Understanding phosphate metabolism in cancer and metastasis". Grantome. Retrieved 2019-03-17.
  22. ^ "The Sidney Kimmel Foundation for Cancer Research Announces 2013 Grant Recipients". PRWeb. Retrieved 2019-03-17.
  23. ^ "Our Scholars". Sidney Kimmel Foundation. Retrieved 2019-03-17.
  24. ^ "Years 2013 - Rita Allen Foundation". Retrieved 2019-03-17.
  25. ^ "UniSysCat: Fiedler, Dorothea". www.unisyscat.tu-berlin.de. Archived from the original on 2021-04-13. Retrieved 2019-03-17.
  26. ^ "EMBO Conference - Chemical Biology 2016 - Speakers". www.embl.de. Retrieved 2019-03-17.
  27. ^ "Speakers | Programme | International Symposium on Bioorganic Chemistry (ISBOC-11) & Konstanz Symposium Chemical Biology | University of Konstanz". www.uni-konstanz.de. Retrieved 2019-03-17.[permanent dead link]
  28. ^ "- NOS History". ACS Division of Organic Chemistry. 4 November 2016. Retrieved 2019-03-17.
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