Draft:Biological noise
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Biological noise, the flip side of biological function, is defined by reproducible events (i.e., not experimental errors) that occur in living cells due to imperfection (i.e., lack of fidelity) of a biological process. [1][2][3]The concept was coined and studied in the Kevin Struhl Laboratory at the Harvard Medical School. The predecessor to the concept is the opinion piece about the transcriptional noise[4], which was defined as non-functional transcription as opposed to the transcriptional noise that reflects gene expression variability. To study biological noise, researcher Zlata Gvozdenov introduced in the cells random DNA sequence artificial chromosome, which is functionally irrelevant.[1] She then compared those molecular events to the endogenous, functional chromosomes. By definition, all events associated with the random sequence chromosome, which is not needed for the cellular functions, are biological noise. Results suggested that the amount of biological noise in the yeast cells is comparable to the functional molecular events, challenging canonical approach to biology that aims to find a functional connection behind every biomolecular event.[3][5]
References
[edit]- ^ a b Gvozdenov, Zlata; Barcutean, Zeno; Struhl, Kevin (2023-06-01). "Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells". Molecular Cell. 83 (11): 1786–1797.e5. doi:10.1016/j.molcel.2023.04.010. ISSN 1097-2765.
- ^ "ScienceDirect.com | Science, health and medical journals, full text articles and books". www.sciencedirect.com. Retrieved 2024-08-02.
- ^ a b Fragile Nucleosome (2022-12-29). Zlata Gvozdenov: Distinguishing Biological Function from Biological Noise. Retrieved 2024-08-02 – via YouTube.
- ^ Struhl, Kevin (February 2007). "Transcriptional noise and the fidelity of initiation by RNA polymerase II". Nature Structural & Molecular Biology. 14 (2): 103–105. doi:10.1038/nsmb0207-103. ISSN 1545-9985.
- ^ Dr. Joel Duff (2023-05-21). Random-Sequence Chromosome Organizes Itself and Transcribes at High Level. Retrieved 2024-08-02 – via YouTube.