Draft:Dr. Xin Yan
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| Education | Purdue University (2009-2015) |
|---|---|
| Fields | Analytical Chemistry
Biochemistry Synthetic Chemistry |
Dr. Xin Yan is an American analytical chemist whose work focuses mainly on mass spectrometry and microdroplet chemistry. Her career started at Stanford University, and eventually she started her work at Texas A&M University.[1] She has received many awards during her career and made many publications.
Education[edit]
After completing her undergraduate degree, Dr. Yan continued with her master’s program at Purdue University.[1] From 2009 - 2010, she completed her program and received a Master’s of Science degree in Health Science. During this time, Yan worked as a research assistant in a chemistry lab. Her work was focused on the synthesis and characterization of different bioorganic compounds and how they can be used to image tumors on mice.
Immediately following, from 2011-2015, Yan remained at Purdue University to receive her PhD in Analytical Chemistry. Her research as a PhD student involved working with mass spectrometry (MS) for studying enzymatic reactions and working on ways to improve the technique. She and Professor Graham Cooks introduced in-line analysis of hydrogenation and cross-coupling reactions using MS, targeted for the benefit for process chemistry in industries.[2] This was useful in that controlling a reaction helps ensure its success and the accuracy of the collected results.
Independent Career[edit]
Once receiving her doctoral degree, Yan started working at Stanford University in 2016. Her research there began work with microdroplet chemistry and different ways to utilize mass spectrometry. In 2019, Yan started her new position at Texas A&M University as a researcher in analytical chemistry where she continued her work. Her research group focuses on microdroplet chemistry and using mass spectrometry to analyze these reactions.[3] This work is to help with disease diagnosis and to improve the medicinal field. Research done in this lab can be applied to cancer research and other biological fields. Though her work is still centered on analytical chemistry, biological chemistry and synthetic chemistry are a large part of her research.[1][3]
Texas A&M University[edit]
Yan introduced a new method to determine the position of double bonds in large molecules (lipids) via rapid epoxidation and subsequentESI-MS, eliminating the need for an extra apparatus to yield the same results.[4]
Awards and Honors[edit]
Between the years of 2021 and 2024, Yan has received 10 awards in the chemistry field.[1]
- 2021, American Society for Mass Spectrometry (ASMS) Research Award[5]
- 2021, NIH Maximizing Investigators' Research (MIRA) Award
- 2022, NSF Faculty Early Career Development Program (CAREER) Award[6]
- 2022, Montague-Center for Teaching Excellence Scholar Award[7]
- 2022, Chinese American Society for Mass Spectrometry (CASMS) Young Investigator Award[8]
- 2022, Okeanos-CAPA Young Investigator Award at the Chemistry & Biology Interface[9]
- 2023, IUPAC Emerging Innovator Award in Analytical Chemistry[10]
- 2023, Association of Former Students (AFS) College-Level Distinguished Achievement Teaching Award
- 2023, ASCEND: Research Leadership Fellow
- 2024, Arthur F. Findeis Award for Achievements by a Young Analytical Scientist
Publications[edit]
From 2007 - 2019, Yan has had 24 publications out.[1][11] Since starting at Texas A&M, Yan has 26 publications in various journals. Some select ones include:
- S. Tang, H. Cheng, X. Yan. On‐Demand Electrochemical Epoxidation in Nano‐Electrospray Ionization Mass Spectrometry to Locate Carbon‐Carbon Double Bonds. Angew. Chem. Int. Ed. 2020, 59, 209-214.[4]
- D. Kuai, H. Cheng, K. Kuan, X. Yan, Accelerated Five-Component Spiro-Pyrrolidine Construction at The Air-Liquid Interface, Chem. Commun, 2021, 57, 3757-3760.[12]
- S. Tang, L. Fan, H. Cheng, X. Yan, Incorporating Electro-Epoxidation into Electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Negatively and Positively Charged Unsaturated Glycerophospholipids. J. Am. Soc. Mass Spectrom. 2021, 32, 2288–2295[13]
- 41. S. Kuo, S. Tang, D. H. Russell, X. Yan. Characterization of Lipid Carbon–Carbon Double-Bond Isomerism via Ion Mobility-Mass Spectrometry (IMS-MS) Combined with Cuprous Ion-Induced Fragmentation. Int. J. Mass Spectrom. 2022, 479, 116889. DOI: 10.1016/j.ijms.2022.116889[14]
- H. Cheng, T. Yang, M. Edwards, S. Tang, S. Xu, X. Yan, Picomole-Scale Transition Metal Electrocatalysis Screening Platform for Discovery of Mild C–C Coupling and C–H Arylation through in Situ Anodically Generated Cationic Pd, J. Am. Chem. Soc. 2022, 144, 1306–1312[15]
- E. Hirtzel, M. Edwards, D. Freitas, Z. Liu, F. Wang, X. Yan, Aziridination-Assisted Mass Spectrometry of Nonpolar Sterol Lipids with Isomeric Resolution, J. Am. Soc. Mass Spectrom. 2023, DOI: 10.1021/jasms.3c00161. Published in the special focus issue “Ion Chemistry and Electrospray Ionization” in honor of Evan Williams.[16]
- T. Yang, S. Tang, J. Feng, X. Yan, Lipid Isobaric Mass Tagging for Enhanced Relative Quantification of Unsaturated sn-Positional Isomers. ACS Measurement Science Au. 2024, online.[17]
References[edit]
- ^ a b c d e "Xin Yan | Department of Chemistry | Texas A&M University". www.chem.tamu.edu. Retrieved 2024-03-22.
- ^ Yan, Xin; Sokol, Ewa; Li, Xin; Li, Guangtao; Xu, Shiqing; Cooks, R. Graham (2014-06-02). "On-Line Reaction Monitoring and Mechanistic Studies by Mass Spectrometry: Negishi Cross-Coupling, Hydrogenolysis, and Reductive Amination". Angewandte Chemie International Edition. 53 (23): 5931–5935. doi:10.1002/anie.201310493. ISSN 1433-7851. PMID 24753222.
- ^ a b "Dr. Xin Yan Group - Research". sites.google.com. Retrieved 2024-03-22.
- ^ a b Tang, Shuli; Cheng, Heyong; Yan, Xin (2020-01-02). "On-Demand Electrochemical Epoxidation in Nano-Electrospray Ionization Mass Spectrometry to Locate Carbon–Carbon Double Bonds". Angewandte Chemie International Edition. 59 (1): 209–214. doi:10.1002/anie.201911070. ISSN 1433-7851. PMID 31639243.
- ^ "Research Awards". www.asms.org. Retrieved 2024-03-22.
- ^ Hutchins, Shana K. "Texas A&M Chemist Xin Yan Earns NSF CAREER Award". artsci.tamu.edu. Retrieved 2024-03-22.
- ^ Henton, Lesley (2022-08-29). "32nd Annual Montague-Center For Teaching Excellence Scholars Award Recipients Announced 32nd Annual Montague-Center For Teaching Excellence Scholars Award Recipients Announced". Texas A&M Today. Retrieved 2024-03-22.
- ^ "2nd CASMS Awards [2022]". casms.org. Retrieved 2024-03-22.
- ^ "CAPA Awards". Capa. Retrieved 2024-03-22.
- ^ Meyers, Fabienne (2023-11-22). "The 2023 Awards in Analytical Chemistry". IUPAC | International Union of Pure and Applied Chemistry. Retrieved 2024-03-22.
- ^ "Dr. Xin Yan Group - Publications and Patents". sites.google.com. Retrieved 2024-03-22.
- ^ Kuai, Dacheng; Cheng, Heyong; Kuan, Kai-Yuan; Yan, Xin (2021-04-15). "Accelerated five-component spiro-pyrrolidine construction at the air–liquid interface". Chemical Communications. 57 (31): 3757–3760. doi:10.1039/D1CC00574J. ISSN 1364-548X. PMID 33876122.
- ^ Tang, Shuli; Fan, Licheng; Cheng, Heyong; Yan, Xin (2021-09-01). "Incorporating Electro-Epoxidation into Electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Negatively and Positively Charged Unsaturated Glycerophospholipids". Journal of the American Society for Mass Spectrometry. 32 (9): 2288–2295. doi:10.1021/jasms.0c00356. ISSN 1044-0305. PMID 33232136.
- ^ Kuo, Syuan-Ting; Tang, Shuli; Russell, David H.; Yan, Xin (September 2022). "Characterization of lipid carbon–carbon double-bond isomerism via ion mobility-mass spectrometry (IMS-MS) combined with cuprous ion-induced fragmentation". International Journal of Mass Spectrometry. 479: 116889. Bibcode:2022IJMSp.479k6889K. doi:10.1016/j.ijms.2022.116889. PMC 10421641. PMID 37577146.
- ^ Cheng, Heyong; Yang, Tingyuan; Edwards, Madison; Tang, Shuli; Xu, Shiqing; Yan, Xin (2022-01-26). "Picomole-Scale Transition Metal Electrocatalysis Screening Platform for Discovery of Mild C–C Coupling and C–H Arylation through in Situ Anodically Generated Cationic Pd". Journal of the American Chemical Society. 144 (3): 1306–1312. doi:10.1021/jacs.1c11179. ISSN 0002-7863. PMID 35015550.
- ^ Hirtzel, Erin; Edwards, Madison; Freitas, Dallas; Liu, Ziying; Wang, Fen; Yan, Xin (2023-09-06). "Aziridination-Assisted Mass Spectrometry of Nonpolar Sterol Lipids with Isomeric Resolution". Journal of the American Society for Mass Spectrometry. 34 (9): 1998–2005. doi:10.1021/jasms.3c00161. ISSN 1044-0305. PMC 10863044. PMID 37523498.
- ^ Yang, Tingyuan; Tang, Shuli; Feng, Jiaxin; Yan, Xin (2024-01-11). "Lipid Isobaric Mass Tagging for Enhanced Relative Quantification of Unsaturated sn -Positional Isomers". ACS Measurement Science Au. doi:10.1021/acsmeasuresciau.3c00062. ISSN 2694-250X.