Draft:LSN2463359
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picolinamide.png)
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| Names | |
|---|---|
| IUPAC name
N-propan-2-yl-5-(2-pyridin-4-ylethynyl)pyridine-2-carboxamide
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| Identifiers | |
PubChem CID
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| Properties | |
| C16H15N3O | |
| Molar mass | 265.316 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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LSN2463359 is a drug used in scientific research.
Mechanism of action
[edit]LSN2463359 is a positive allosteric modulator of the mGluR5[1][2], which means it increases the activity of glutamate (an excitatory neurotransmitter) at this receptor.
Potential uses
[edit]A study has found that LSN2463359 and similar drugs can be used as a treatment to some aspects of cognitive deficits in schizophrenia.[3] Another study also mention that it could be used in the treatment of schizophrenia due to the potential interactions between NMDA receptors and mGluR5.[4]
References
[edit]- ^ "LSN2463359 | mGlu5 Modulator | MedChemExpress".
- ^ Gilmour, Gary; Broad, Lisa M.; Wafford, Keith A.; Britton, Thomas; Colvin, Ellen M.; Fivush, Adam; Gastambide, Francois; Getman, Brian; Heinz, Beverly A.; McCarthy, Andrew P.; Prieto, Lourdes; Shanks, Elaine; Smith, Janice W.; Taboada, Lorena; Edgar, Dale M. (January 2013). "In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat". Neuropharmacology. 64: 224–239. doi:10.1016/j.neuropharm.2012.07.030. ISSN 1873-7064. PMID 22884720.
- ^ Gastambide, Francois; Cotel, Marie-Caroline; Gilmour, Gary; O'Neill, Michael J.; Robbins, Trevor W.; Tricklebank, Mark D. (March 2012). "Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator". Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 37 (4): 1057–1066. doi:10.1038/npp.2011.298. ISSN 1740-634X. PMC 3280638. PMID 22129780.
- ^ Gastambide, Francois; Gilmour, Gary; Robbins, Trevor W.; Tricklebank, Mark D. (January 2013). "The mGlu₅ positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat". Neuropharmacology. 64: 240–247. doi:10.1016/j.neuropharm.2012.07.039. ISSN 1873-7064. PMID 22884612.