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Draft:List of chronic pain syndromes

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Ascending pain pathways
Pain signals are carried from sensory nerves to the brain. Nociceptors from the body and some visceral organs convey signals to the spinal cord. These ascend to the brain along the spinothalamic and spinobulbar pathways. Nociceptors from the face convey signals to the trigeminal nucleus. Some visceral organs convey pain signals along the vagus nerve to the solitary nucleus. Discriminatory pain information is conveyed to the somatosensory cortex. Affective components of pain are conveyed to multiple cortical areas.

Chronic pain is defined as reoccurring or persistent pain that lasts for over 3 months.[1] Chronic pain continues past normal healing times and therefore does not have the same function as acute pain.[2] Acute pain serves to signal the body that there is a threat so that the body can avoid future danger. Chronic pain on the other hand does not serve this purpose.[3] The International Association for the Study of Pain (IASP) defines pain as "An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage".[4] Chronic pain is considered a syndrome because of the associated symptoms that develop in those experiencing chronic pain.[5] Chronic pain is a prevalent condition that affects approximately 20% of people and accounts for 15-20% of visits to a physician.[2]

Pain can be categorized according to its location, cause, or the anatomical system in which it affects. Pain can also defy these classifications which makes it difficult to classify chronic pain. In order to create a classification system for chronic pain, the International Association for the Study of Pain (IASP) collaborated with the World Health Organization (WHO) to form a Task Force for the Classification of Chronic Pain. The IASP Task Force was made up of those who were experts in pain and developed a new model to classify chronic pain for the ICD-11. The IASP Task Force emphasized the cause of pain, underlying mechanisms and body sites.[2] This classification system differentiates chronic primary pain from chronic secondary pain, incorporates already existing diagnosis, and further characterizes chronic pain syndromes. The ICD-11 category for chronic pain includes the most common types of chronic pain, chronic primary pain, chronic cancer pain, chronic posttraumatic and postsurgical pain, chronic neuropathic pain, chronic secondary headache and orofacial pain, chronic secondary visceral pain, and chronic secondary musculoskeletal pain. There can also be significant overlap between several categories.[6]

Chronic primary pain

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Chronic primary pain is pain that affects one or more anatomical sites, reoccurs or persists for more than three months, causes emotional distress or functional disability and can't be better explained by another chronic pain condition.[7] Emotional distress can be expressed in a number of ways such as frustration, anxiety, depression, demoralization and anger. Functional disability encompasses a large range of difficulties such as difficulties at work, difficulties with sleeping, or difficulties with social activities. Chronic primary pain can affect any body system or site and can also be widespread.[8] Conditions within this category are further classified into chronic widespread pain, complex regional pain syndromes, chronic primary headache and orofacial pain, chronic primary visceral pain, and chronic primary musculoskeletal pain.[7]

Chronic widespread pain

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Chronic widespread pain is defined as diffuse musculoskeletal pain affecting at least three to four body regions and in at least three or more body quadrants and axial skeleton. Body quadrants are defined as upper, lower, left and right sides of the body. Chronic widespread pain cannot be attributed to nociceptive process in these areas.[9]

Complex regional pain syndromes

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A 60 years old male patient suffering from type I CRPS, majorly caused by left tibial fracture. Picture taken after 6 months of the injury.

Complex regional pain syndrome is characterized by pain that is distributed regionally, usually starts in an extremity distally, occurs after a trauma, and the pain is disproportionate in severity or duration compared to the expected course of the trauma. Complex regional pain syndrome is divided into two types, type 2 requires evidence of peripheral nerve injury, while type 1 does not.[9]

  • Complex regional pain syndrome type I
  • Complex regional pain syndrome type II

Chronic primary headache and orofacial pain

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Chronic primary headache or orofacial pain is orofacial pain or headache that persists for longer than three months and occurs at least 15 days a month. When untreated the pain lasts at least two hours or can occur as many shorter episodes of pain throughout the day.[9]

Chronic primary visceral pain

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Chronic primary visceral pain occurs in the head or neck viscera of the digestive system; the abdominal area from viscera of the digestive system, such as IBS; the thoracic region, such as non-cardiac chest pain; and the pelvic area from the involvement of viscera of the urinary, digestive, and genital systems, such as chronic pelvic pain.[10]

Chronic primary musculoskeletal pain

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Chronic primary musculoskeletal pain affects the joints, muscles, bones, or tendons. Chronic primary musculoskeletal pain syndromes are classified by the location in which they affect.[11]

  • Chronic primary low back pain
  • Chronic primary cervical pain
  • Chronic primary thoracic pain
  • Chronic primary limb pain

Chronic secondary pain

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Chronic secondary pain syndromes are caused by other medical conditions. Pain may initially be a symptom of a disease however it can also persist after successful treatment of the underlying disorder. Chronic secondary pain can be further categorized into chronic cancer-related pain, chronic postsurgical or posttraumatic pain, chronic neuropathic pain, chronic secondary headache or orofacial pain, chronic secondary visceral pain, and chronic secondary musculoskeletal pain.[12]

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Pain is the most common symptom of cancer at the time of diagnosis. Cancer-related pain can be caused by metastases, the tumour itself, inflamed or eroding bone viscera or nerves, or pain related to cancer treatments.[13] The term “cancer-related pain” only indicates that pain is related to cancer and doesn't imply the exact cause of the pain.[14]

Chronic cancer pain

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Chronic cancer pain is caused by metastases or primary cancer. It has neuropathic and inflammatory mechanisms that are caused by how tissue responds to tumours or metastases.[14]

  • Chronic visceral cancer pain
  • Chronic bone cancer pain
  • Chronic neuropathic cancer pain

Chronic post cancer treatment pain

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Cancer treatments can also contribute to chronic pain. Cancer treatments include chemotherapy, surgery, and radiotherapy, which are known to cause chronic pain.[15]

  • Chronic post cancer medicine pain
  • Chronic painful chemotherapy-induced polyneuropathy
  • Chronic post radiotherapy pain
  • Chronic painful radiation-induced neuropathy
  • Chronic postcancer surgery pain

Chronic postsurgical or posttraumatic pain

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Chronic postsurgical or posttraumatic pain is pain that develops of becomes more severe following surgery or an injury. Chronic postsurgical or posttraumatic pain continues past the expected timeframe for healing (typically three months). The pain is localized to the site of injury or surgery.[16]

Chronic post traumatic pain

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Chronic post traumatic pain is pain that develops are worsens after an injury. The pain is either localized to the injured region, referred to a dermatomal region, or innervation territory of the nerves in the area.[17]

Chronic postsurgical pain

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Chronic postsurgical pain refers to pain that develops or becomes more severe after a surgical procedure.[18]

Chronic neuropathic pain

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Chronic neuropathic pain is caused by a disease or lesion of the somatosensory nervous system. Chronic neuropathic pain requires a history of nervous system injury or disease as well as a distribution of pain that makes sense in the context of neuroanatomy.[19]

Chronic central neuropathic pain

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Chronic central neuropathic pain is caused by a lesion or disease of the central somatosensory nervous system.[20]

Chronic peripheral neuropathic pain

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Chronic central neuropathic pain is caused by a lesion or disease of the peripheral somatosensory nervous system.[19]

Chronic secondary headache or orofacial pain

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Chronic secondary headache or orofacial pain is a result of an underlying disorder.[21] Chronic secondary headache or orofacial pain can be caused by ischemic stroke, nontraumatic intracranial hemorrhage, arteritis, cervical carotid or vertebral artery disorder, unruptured vascular malformation, pituitary apoplexy, genetic vasculopathy, increased cerebrospinal fluid pressure, Chiari malformation type I, low cerebrospinal fluid pressure, intracranial neoplasms, intrathecal injection, noninfectious inflammatory intracranial disease, epileptic seizure, substance withdrawal,[21] bacterial meningitis, subdural empyema, meningoencephalitis, viral meningitis or encephalitis, brain abscess, intracranial fungal or other parasitic infections, hypoxia, hypercapnia, cardiac cephalalgia, dialysis, fasting, arterial hypertension, and hypothyroidism.[22]

  • Chronic dental pain
  • Chronic neuropathic orofacial pain
  • Headache or orofacial pain associated with chronic secondary temporomandibular disorders
  • Chronic headache or orofacial pain associated with disorders of homoeostasis or their nonpharmacological treatment
  • Chronic headache or orofacial pain associated with cranial or cervical vascular disorder
  • Chronic headache or orofacial pain associated with non-vascular intracranial disorder
  • Chronic headache associated with a substance or its withdrawal
  • Chronic headache or orofacial pain attributed to trauma or injury to the head and/or neck
  • Chronic headache or orofacial pain attributed to infection

Chronic secondary visceral pain

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Chronic secondary visceral pain refers to reoccurring or persisting pain caused by organs in the thoracic, abdominal, and pelvic cavities.[23]

Chronic visceral pain from mechanical factors

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Chronic visceral pain from mechanical factors is caused by external compression of internal organs, internal organ traction involving ligaments and vessels, or internal obstructions, such as stones or stenosis, which can block hollow viscera and cause dilation above the obstruction.[24]

  • Chronic visceral pain from mechanical factors in the head or neck region
  • Chronic visceral pain from mechanical factors in the thoracic region
  • Chronic visceral pain from mechanical factors in the abdominal region
  • Chronic visceral pain from mechanical factors in the pelvic region

Chronic visceral pain from vascular mechanisms

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Chronic visceral pain from vascular mechanisms is caused by changes in the arterial or venous blood vessels that supply blood to the viscera of the thoracic, abdominal and pelvic cavities and the head or neck region. It can also be caused by a disorder of the vascular system that causes pain in other areas of the body.[25]

  • Chronic visceral pain from vascular mechanisms in the head or neck region
  • Chronic visceral pain from vascular mechanisms in the thoracic region
  • Chronic visceral pain from vascular mechanisms in the abdominal region
  • Chronic visceral pain from vascular mechanisms in the pelvic region

Chronic visceral pain from persistent inflammation

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Chronic visceral pain from persistent inflammation is pain caused by chronic inflammation of internal organs. This inflammation can be caused by noninfectious, infectious, or autoimmune mechanisms.[23]

  • Chronic visceral pain from persistent inflammation in the head or neck region
  • Chronic visceral pain from persistent inflammation in the thoracic region
  • Chronic visceral pain from persistent inflammation in the abdominal region
  • Chronic visceral pain from persistent inflammation in the pelvic region

Chronic secondary musculoskeletal pain

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Chronic secondary musculoskeletal pain can be caused by a variety of conditions, including chronic nociception in the vertebral column, joints, bones, muscles, tendons, and soft tissues, as well as deep somatic lesions.[26]

Chronic secondary musculoskeletal pain from persistent inflammation

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One of the main causes of many musculoskeletal disorders is inflammation. Similarly, one of the main causes of persistent musculoskeletal pain is ongoing inflammation. Inflammation-related pain symptoms include heightened sensitivity to stimuli in the afflicted area. In rheumatological disorders with inflammation as the principal pathophysiological mechanism, chronic secondary musculoskeletal pain can be the main symptom.[26]

Chronic secondary musculoskeletal pain associated with structural changes

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Chronic secondary musculoskeletal pain associated with structural changes can be attributed to modifications in the structure of a joint, bone, or tendon. The structural alteration can be seen on imaging or determined from a clinical assessment.[27]

  • Chronic secondary musculoskeletal pain associated with osteoarthritis
  • Chronic secondary musculoskeletal pain associated with spondylosis
  • Chronic pain after musculoskeletal injury

Chronic secondary musculoskeletal pain due to disease of the nervous system

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Chronic secondary musculoskeletal pain due to disease of the nervous system is associated with central or peripheral nervous system conditions that are categorized elsewhere. It involves pain brought on by changes in sensory and motor function.[27]

Referances

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Citations

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Sources

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Further reading

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