Draft:Orly Alter

From Wikipedia, the free encyclopedia
  • Comment: The subject's own publications can not be used as sources for an article about himself. His profile on institutions are only acceptable if there are other sources that already demonstrate the subject's notability, which it currently has none. Please make sure to include several non-trivial coverage from independent and trustworthy sources to prove that the subject meets WP:NACADEMIC or WP:NBIO, and make sure to address the concern brought up by the previous comment as well. Tutwakhamoe (talk) 02:07, 10 July 2023 (UTC)
  • Comment: Please ensure all statements are sourced, including the date of birth, and see also WP:COI. Greenman (talk) 06:59, 10 April 2023 (UTC)

Orly Alter
Born
Orly Alter

(1964-04-12) 12 April 1964 (age 60)
Tel Aviv, Israel
Academic background
Alma mater
ThesisQuantum Measurement of a Single System (1999)
Doctoral advisorYoshihisa Yamamoto

Orly Alter (born April 12, 1964) is an Israeli-American physicist and research associate professor in the field of bioengineering and human genetics. She has published several papers about her research in genomic signal processing and bladder and brain cancers. She is a professor at the University of Utah[1].

Early life and education[edit]

Alter was born on April 12, 1964, in Tel Aviv, Israel. As is custom in Israel, she partook in the country’s mandatory military service, acting as an Operations Researcher at the Israeli Air Force Headquarters from 1982 until 1983, and finishing up her service working as a Base Defense Officer in the Israeli Air Force from 1983 until 1985 when she was honorably discharged, leaving with the rank of First Lieutenant.[1]

She began attending school at Tel Aviv University in Israel and graduated in October 1989 magna cum laude with her Bachelors of Science in Physics. After receiving her undergrad, she began pursuing her Ph.D. in applied physics at the Stanford University in California, USA. She completed her Ph.D. with a thesis on “Quantum Measurement of a Single System,"[2] under the mentorship of Yoshihisa Yamamoto in January of 1999 and then moved onto a postdoctoral fellowship working with genetics, remaining at Stanford. She completed this fellowship in January of 2004.[1]

Career and research[edit]

Alter is currently working at the University of Utah [1]. She has one published book named Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling of Large-Scale Molecular Biological Data.[3] She has contributed to a lot of research about genetics and physics. Alter has eighteen journal papers published along with nine technical reports. She also holds six patents in both the US and internationally. [1]

Awards and recognition[edit]

Nominated

  • 1998 - “Outstanding Doctoral Thesis Research in Atomic, Molecular, or Optical Physics (DAMOP) Award" by Quantum Measurement of a Single System[8]

Selected publications[edit]

  • Inhibition of the measurement of the wave function of a single quantum system in repeated weak quantum nondemolition measurements[9]
  • Singular value decomposition for genome-wide expression data processing and modeling[10]
  • Quantum Measurement of a Single System[11]
  • Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms[12]
  • Integrative analysis of genome-scale data by using pseudoinverse projection predicts novel correlation between DNA replication and RNA transcription[13]
  • Reconstructing the pathways of a cellular system from genome-scale signals by using matrix and tensor computations[14]
  • Singular value decomposition of genome-scale mRNA lengths distribution reveals asymmetry in RNA gel electrophoresis band broadening[15]
  • Discovery of principles of nature from mathematical modeling of DNA microarray data[16]
  • A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies[17]
  • Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression[18]
  • Tensor decomposition reveals concurrent evolutionary convergences and divergences and correlations with structural motifs in ribosomal RNA[19]
  • A higher-order generalized singular value decomposition for comparison of global mRNA expression from multiple organisms[20]
  • GSVD comparison of patient-matched normal and tumor aCGH profiles reveals global copy-number alterations predicting glioblastoma multiforme survival[21]
  • SVD identifies transcript length distribution functions from DNA microarray data and reveals evolutionary forces globally affecting GBM metabolism[22]
  • Tensor GSVD of patient- and platform-matched tumor and normal DNA copy-number profiles uncovers chromosome arm-wide patterns of tumor-exclusive platform-consistent alterations encoding for cell transformation and predicting ovarian cancer survival[23]
  • Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition[24]
  • Mathematically universal and biologically consistent astrocytoma genotype encodes for transformation and predicts survival phenotype[25]
  • GSVD- and tensor GSVD-uncovered patterns of DNA copy-number alterations predict adenocarcinomas survival in general and in response to platinum[26]
  • Multi-Tensor Decompositions for Personalized Cancer Diagnostics, Prognostics, and Therapeutics
  • Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival [27]

References[edit]

  1. ^ a b c d e "ORLY ALTER - Home - Faculty Profile - The University of Utah". faculty.utah.edu. Retrieved 13 March 2023.
  2. ^ Alter, Orly, Yamamoto, Yoshihisa (2001). Quantum Measurement of a Single System (1st ed.). Wiley-VCH. ISBN 978-0471283089.{{cite book}}: CS1 maint: multiple names: authors list (link)
  3. ^ Alter, Orly. Genomic Signal Processing: Discovery of Principles of Nature from Matrix and Tensor Modeling. Wiley. ISBN 978-1119078371.
  4. ^ "Analytical and Computational Tools for Genome-Wide Gene Expression Data Analysis - Dimensions". app.dimensions.ai. Retrieved 13 March 2023.
  5. ^ "MATHEMATICAL TOOLS FOR GENE EXPRESSION DATA ANALYSIS - Dimensions". app.dimensions.ai. Retrieved 13 March 2023.
  6. ^ "CAREER: Integrative and Comparative Tensor Algebra Models of DNA Microarray Data from Different Studies of the Cell Cycle - Dimensions". app.dimensions.ai. Retrieved 13 March 2023.
  7. ^ "AAPM Science Council Session Winner (SCSW) Recipients". aapm.org. Retrieved 13 March 2023.
  8. ^ "DAMOP Thesis Award". aps.org. Retrieved 13 March 2023.
  9. ^ Alter, Orly; Yamamoto, Yoshihisa (22 May 1995). "Inhibition of the Measurement of the Wave Function of a Single Quantum System in Repeated Weak Quantum Nondemolition Measurements". Physical Review Letters. 74 (21): 4106–4109. Bibcode:1995PhRvL..74.4106A. doi:10.1103/PhysRevLett.74.4106. ISSN 0031-9007. PMID 10058417.
  10. ^ Alter, Orly; Brown, Patrick O.; Botstein, David (29 August 2000). "Singular value decomposition for genome-wide expression data processing and modeling". Proceedings of the National Academy of Sciences. 97 (18): 10101–10106. Bibcode:2000PNAS...9710101A. doi:10.1073/pnas.97.18.10101. ISSN 0027-8424. PMC 27718. PMID 10963673.
  11. ^ Alter, Orly; Yamamoto, Yoshihisa (5 July 2001). Quantum Measurement of a Single System (1 ed.). Wiley. doi:10.1002/9783527617128. ISBN 978-0-471-28308-9.
  12. ^ Alter, Orly; Brown, Patrick O.; Botstein, David (18 March 2003). "Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms". Proceedings of the National Academy of Sciences. 100 (6): 3351–3356. Bibcode:2003PNAS..100.3351A. doi:10.1073/pnas.0530258100. ISSN 0027-8424. PMC 152296. PMID 12631705.
  13. ^ Alter, Orly; Golub, Gene H. (23 November 2004). "Integrative analysis of genome-scale data by using pseudoinverse projection predicts novel correlation between DNA replication and RNA transcription". Proceedings of the National Academy of Sciences. 101 (47): 16577–16582. Bibcode:2004PNAS..10116577A. doi:10.1073/pnas.0406767101. ISSN 0027-8424. PMC 534520. PMID 15545604.
  14. ^ Alter, Orly; Golub, Gene H. (6 December 2005). "Reconstructing the pathways of a cellular system from genome-scale signals by using matrix and tensor computations". Proceedings of the National Academy of Sciences. 102 (49): 17559–17564. Bibcode:2005PNAS..10217559A. doi:10.1073/pnas.0509033102. ISSN 0027-8424. PMC 1308929. PMID 16314560.
  15. ^ Alter, Orly; Golub, Gene H. (8 August 2006). "Singular value decomposition of genome-scale mRNA lengths distribution reveals asymmetry in RNA gel electrophoresis band broadening". Proceedings of the National Academy of Sciences. 103 (32): 11828–11833. Bibcode:2006PNAS..10311828A. doi:10.1073/pnas.0604756103. ISSN 0027-8424. PMC 1524674. PMID 16877539.
  16. ^ Alter, Orly (31 October 2006). "Discovery of principles of nature from mathematical modeling of DNA microarray data". Proceedings of the National Academy of Sciences. 103 (44): 16063–16064. Bibcode:2006PNAS..10316063A. doi:10.1073/pnas.0607650103. ISSN 0027-8424. PMC 1637536. PMID 17060616.
  17. ^ Omberg, Larsson; Golub, Gene H.; Alter, Orly (20 November 2007). "A tensor higher-order singular value decomposition for integrative analysis of DNA microarray data from different studies". Proceedings of the National Academy of Sciences. 104 (47): 18371–18376. Bibcode:2007PNAS..10418371O. doi:10.1073/pnas.0709146104. ISSN 0027-8424. PMC 2147680. PMID 18003902.
  18. ^ Omberg, Larsson; Meyerson, Joel R; Kobayashi, Kayta; Drury, Lucy S; Diffley, John F X; Alter, Orly (January 2009). "Global effects of DNA replication and DNA replication origin activity on eukaryotic gene expression". Molecular Systems Biology. 5 (1): 312. doi:10.1038/msb.2009.70. ISSN 1744-4292. PMC 2779084. PMID 19888207.
  19. ^ Alter, Orly. "Orly Alter - Genomic Signal Processing Lab - Publications - Muralidhara, Gross, Gutell and Alter, PLoS One 2011". alterlab.org. Retrieved 14 March 2023.
  20. ^ Ponnapalli, Sri Priya; Saunders, Michael A.; Van Loan, Charles F.; Alter, Orly (22 December 2011). Zhu, Dongxiao (ed.). "A Higher-Order Generalized Singular Value Decomposition for Comparison of Global mRNA Expression from Multiple Organisms". PLOS ONE. 6 (12): e28072. Bibcode:2011PLoSO...628072P. doi:10.1371/journal.pone.0028072. ISSN 1932-6203. PMC 3245232. PMID 22216090.
  21. ^ Lee, Cheng H.; Alpert, Benjamin O.; Sankaranarayanan, Preethi; Alter, Orly (23 January 2012). Bader, Joel S. (ed.). "GSVD Comparison of Patient-Matched Normal and Tumor aCGH Profiles Reveals Global Copy-Number Alterations Predicting Glioblastoma Multiforme Survival". PLOS ONE. 7 (1): e30098. Bibcode:2012PLoSO...730098L. doi:10.1371/journal.pone.0030098. ISSN 1932-6203. PMC 3264559. PMID 22291905.
  22. ^ Bertagnolli, Nicolas M.; Drake, Justin A.; Tennessen, Jason M.; Alter, Orly (25 November 2013). Pellegrini, Matteo (ed.). "SVD Identifies Transcript Length Distribution Functions from DNA Microarray Data and Reveals Evolutionary Forces Globally Affecting GBM Metabolism". PLOS ONE. 8 (11): e78913. Bibcode:2013PLoSO...878913B. doi:10.1371/journal.pone.0078913. ISSN 1932-6203. PMC 3839928. PMID 24282503.
  23. ^ Sankaranarayanan, Preethi; Schomay, Theodore E.; Aiello, Katherine A.; Alter, Orly (15 April 2015). Hoheisel, Jörg D. (ed.). "Tensor GSVD of Patient- and Platform-Matched Tumor and Normal DNA Copy-Number Profiles Uncovers Chromosome Arm-Wide Patterns of Tumor-Exclusive Platform-Consistent Alterations Encoding for Cell Transformation and Predicting Ovarian Cancer Survival". PLOS ONE. 10 (4): e0121396. Bibcode:2015PLoSO..1021396S. doi:10.1371/journal.pone.0121396. ISSN 1932-6203. PMC 4398562. PMID 25875127.
  24. ^ Aiello, Katherine A.; Alter, Orly (31 October 2016). Peddada, Shyamal D (ed.). "Platform-Independent Genome-Wide Pattern of DNA Copy-Number Alterations Predicting Astrocytoma Survival and Response to Treatment Revealed by the GSVD Formulated as a Comparative Spectral Decomposition". PLOS ONE. 11 (10): e0164546. Bibcode:2016PLoSO..1164546A. doi:10.1371/journal.pone.0164546. ISSN 1932-6203. PMC 5087864. PMID 27798635.
  25. ^ Aiello, Katherine A.; Ponnapalli, Sri Priya; Alter, Orly (September 2018). "Mathematically universal and biologically consistent astrocytoma genotype encodes for transformation and predicts survival phenotype". APL Bioengineering. 2 (3): 031909. doi:10.1063/1.5037882. ISSN 2473-2877. PMC 6215493. PMID 30397684.
  26. ^ Bradley, Matthew W.; Aiello, Katherine A.; Ponnapalli, Sri Priya; Hanson, Heidi A.; Alter, Orly (September 2019). "GSVD- and tensor GSVD-uncovered patterns of DNA copy-number alterations predict adenocarcinomas survival in general and in response to platinum". APL Bioengineering. 3 (3): 036104. doi:10.1063/1.5099268. ISSN 2473-2877. PMC 6701977. PMID 31463421.
  27. ^ Ponnapalli, Sri Priya; Bradley, Matthew W.; Devine, Karen; Bowen, Jay; Coppens, Sara E.; Leraas, Kristen M.; Milash, Brett A.; Li, Fuqiang; Luo, Huijuan; Qiu, Shi; Wu, Kui; Yang, Huanming; Wittwer, Carl T.; Palmer, Cheryl A.; Jensen, Randy L. (1 June 2020). "Retrospective clinical trial experimentally validates glioblastoma genome-wide pattern of DNA copy-number alterations predictor of survival". APL Bioengineering. 4 (2): 026106. doi:10.1063/1.5142559. ISSN 2473-2877. PMC 7229984. PMID 32478280.

External links[edit]

Retrieved from "https://en.wikipedia.org/w/index.php?title=Draft:Orly_Alter&oldid=1190828602"