Draft:Peter Michael Lansdorp
| Submission declined on 27 March 2024 by Drmies (talk). This submission's references do not show that the subject qualifies for a Wikipedia article—that is, they do not show significant coverage (not just passing mentions) about the subject in published, reliable, secondary sources that are independent of the subject (see the guidelines on the notability of people). Before any resubmission, additional references meeting these criteria should be added (see technical help and learn about mistakes to avoid when addressing this issue). If no additional references exist, the subject is not suitable for Wikipedia.
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| Submission declined on 18 January 2024 by Spinster300 (talk). This submission does not appear to be written in the formal tone expected of an encyclopedia article. Entries should be written from a neutral point of view, and should refer to a range of independent, reliable, published sources. Please rewrite your submission in a more encyclopedic format. Please make sure to avoid peacock terms that promote the subject. Declined by Spinster300 4 months ago. | |
| Submission declined on 5 January 2024 by Ldm1954 (talk). This draft's references do not show that the subject qualifies for a Wikipedia article. In summary, the draft needs to
This submission does not appear to be written in the formal tone expected of an encyclopedia article. Entries should be written from a neutral point of view, and should refer to a range of independent, reliable, published sources. Please rewrite your submission in a more encyclopedic format. Please make sure to avoid peacock terms that promote the subject. Declined by Ldm1954 4 months ago. | |
| Submission declined on 31 December 2023 by Eternal Shadow (talk). This submission does not appear to be written in the formal tone expected of an encyclopedia article. Entries should be written from a neutral point of view, and should refer to a range of independent, reliable, published sources. Please rewrite your submission in a more encyclopedic format. Please make sure to avoid peacock terms that promote the subject. Declined by Eternal Shadow 4 months ago. | |
Comment: This draft is better, but there are still too many peacock terms. In addition, currently this lists his research but really does not prove that he is notable. That needs recognition by others. For instance senior fellow of major societies, major awards (not grants). Please read WP:NPROF carefully.Also, the long list of his research ares is not useful unless they are quoted in a major awards. This is not the place for a CV. Ldm1954 (talk) 14:00, 5 January 2024 (UTC)
- Comment: Uses WP:PEACOCK terms on multiple instances, especially to describe the subject of the submission. Eternal Shadow Talk 22:51, 31 December 2023 (UTC)
Peter Michael Lansdorp (born December 16, 1952) is recognized for his contributions in the fields of hematology, medical genetics and cancer research. He has made significant contributions to the understanding of genome instability, particularly in relation to aging and cancer. His research has focused on the biology of blood-forming stem cells, telomeres and genome analysis. He is also known for the development of techniques including single cell Strand-seq and fluorescence in situ hybridization (FISH) techniques such as Q-FISH and flow FISH.[1]
Early Life & Career[edit]
Peter Lansdorp grew up in the Netherlands (Den Haag and Wassenaar). He obtained a Medical Degree from the Erasmus University in Rotterdam in 1976.[1] His early career included work on monoclonal antibodies at Sanquin and he obtained a PhD from the University of Amsterdam in 1985.[citation needed] Between 2011 and 2017, he was the Founding Scientific Director of the European Research Institute for the Biology of Aging at the University of Groningen, the Netherlands. He returned to Vancouver in 2017, resuming his role as a Distinguished Scientist at the Terry Fox Laboratory and a Professor in Hematology and Medical Genetics at the University of British Columbia.[2][3]
Research[edit]
In 1984, Lansdorp made a significant contribution to the field of monoclonal antibodies with the discovery of a method to efficiently form bifunctional tetrameric antibody complexes.[citation needed] This method was patented and later licensed to StemCell Technologies in Vancouver.[4] Lansdorp's early work in Vancouver predominantly focused on experimental hematology. He first demonstrated that the functional properties of purified "candidate" blood forming stem cells, including their self-renewal properties, change dramatically during development.[citation needed] He subsequently showed that telomere repeats are lost in purified hematopoietic stem cells supporting the concept that blood stem cells do not truly "self-renew" but are mortal like most other somatic cells.[citation needed]
Lansdorp also developed a novel fluorescent in situ hybridization (FISH) method to measure the length of telomere repeats using peptide nucleic acid (PNA) probes.[citation needed] He subsequently showed that flow cytometry can be used to measure the average telomere length in individual nucleated blood cells.[citation needed]
In 2002 Lansdorp provided compelling evidence for the formation of guanine quadruplex (G4) DNA structures in C. elegans.[citation needed] He proposed that the dog-1 helicase gene is required to unwind G4 DNA structures that occasionally form during DNA synthesis.[citation needed]
External Links[edit]
References[edit]
- ^ a b "» Peter Lansdorp". neuroscience.umcg.nl. Retrieved 2023-12-31.
- ^ "macgenome.org" (PDF).
- ^ "open.library.ubc.ca".
- ^ US4868109A, Lansdorp, Peter M., "Immunological antibody complex, its preparation and its use", issued 1989-09-19