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ELMO2

From Wikipedia, the free encyclopedia
ELMO2
Identifiers
AliasesELMO2, CED-12, CED12, ELMO-2, Ced-12A, engulfment and cell motility 2, VMPI
External IDsOMIM: 606421; MGI: 2153045; HomoloGene: 44338; GeneCards: ELMO2; OMA:ELMO2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022086
NM_133171
NM_182764
NM_001318253

RefSeq (protein)

NP_001305182
NP_573403
NP_877496

NP_001289681
NP_001289683
NP_525026
NP_997589

Location (UCSC)Chr 20: 46.37 – 46.43 MbChr 2: 165.13 – 165.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Engulfment and cell motility protein 2 is a protein that in humans is encoded by the ELMO2 gene.[5][6]

The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000062598Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017670Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gumienny TL, Brugnera E, Tosello-Trampont AC, Kinchen JM, Haney LB, Nishiwaki K, Walk SF, Nemergut ME, Macara IG, Francis R, Schedl T, Qin Y, Van Aelst L, Hengartner MO, Ravichandran KS (Oct 2001). "CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration" (PDF). Cell. 107 (1): 27–41. doi:10.1016/S0092-8674(01)00520-7. PMID 11595183. S2CID 15232864. Archived from the original (PDF) on 2021-09-22. Retrieved 2020-08-31.
  6. ^ a b "Entrez Gene: ELMO2 engulfment and cell motility 2".

Further reading

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