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EXTL1

From Wikipedia, the free encyclopedia
EXTL1
Identifiers
AliasesEXTL1, EXTL, exostosin-like glycosyltransferase 1, exostosin like glycosyltransferase 1
External IDsOMIM: 601738; MGI: 1888742; HomoloGene: 3277; GeneCards: EXTL1; OMA:EXTL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004455

NM_019578
NM_001355493

RefSeq (protein)

NP_004446

NP_062524
NP_001342422

Location (UCSC)Chr 1: 26.02 – 26.04 MbChr 4: 134.08 – 134.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Exostosin-like 1 is a protein that in humans is encoded by the EXTL1 gene.[5][6]

This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158008Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028838Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wise CA, Clines GA, Massa H, Trask BJ, Lovett M (May 1997). "Identification and localization of the gene for EXTL, a third member of the multiple exostoses gene family". Genome Res. 7 (1): 10–6. doi:10.1101/gr.7.1.10. PMID 9037597.
  6. ^ a b "Entrez Gene: EXTL1 exostoses (multiple)-like 1".

Further reading

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